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'TIMely' intervention for asthma

Date:
August 25, 2010
Source:
Journal of Clinical Investigation
Summary:
TIM1 has been identified as a susceptibility gene for asthma. New research in mice now suggests that targeting TIM-1 protein might have therapeutic benefit in treating this increasingly prevalent condition.
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Asthma can be a severely debilitating disease. Its increasing prevalence and the fact that most treatments do not control severe asthma well has stimulated intensive research into genetic susceptibility to asthma in the hope that the information gleaned will lead to new therapeutics.

One gene identified as a asthma susceptibility gene is TIM1 and now, a team of researchers, led by Paul Rennert, at Biogen Idec Inc., Cambridge, has generated data in a humanized mouse model of asthma that suggest that targeting TIM-1 protein might have therapeutic benefit in the treatment of patients with asthma.

Specifically, the team found that an antibody that bound to a defined region of the TIM-1 protein (a cleft formed within the IgV domain) had therapeutic activity in the humanized mouse model of experimental asthma, ameliorating inflammation and airway hyperresponsiveness.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Sanchaita Sriwal Sonar, Yen-Ming Hsu, Melanie Lynn Conrad, Gerard R. Majeau, Ayse Kilic, Ellen Garber, Yan Gao, Chioma Nwankwo, Gundi Willer, Jan C. Dudda, Hellen Kim, Véronique Bailly, Axel Pagenstecher, Paul D. Rennert and Harald Renz. Antagonism of TIM-1 blocks the development of disease in a humanized mouse model of allergic asthma. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI39543

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Journal of Clinical Investigation. "'TIMely' intervention for asthma." ScienceDaily. ScienceDaily, 25 August 2010. <www.sciencedaily.com/releases/2010/07/100712121824.htm>.
Journal of Clinical Investigation. (2010, August 25). 'TIMely' intervention for asthma. ScienceDaily. Retrieved April 27, 2015 from www.sciencedaily.com/releases/2010/07/100712121824.htm
Journal of Clinical Investigation. "'TIMely' intervention for asthma." ScienceDaily. www.sciencedaily.com/releases/2010/07/100712121824.htm (accessed April 27, 2015).

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