Featured Research

from universities, journals, and other organizations

Parkinson's: New clues to alleviating gait disorders and falls

Date:
July 26, 2010
Source:
Journal of Clinical Investigation
Summary:
Drugs that target the mediator of nerve cell communication dopamine alleviate many of the symptoms of Parkinson's disease but not the gait disorders and falls that affect those with severe disease. New research indicates that drugs targeting nerve cells that communicate using the molecule acetylcholine in the PPN region of the brain might provide a way to alleviate these otherwise untreatable symptoms of Parkinson's disease.

Many of the symptoms of Parkinson disease can be alleviated with drugs that target dompamine, a chemical in the brain that is involved in nerve cell communication and therefore known as a neurotransmitter. However, such drugs do not improve the gait disorders and falls that commonly affect individuals with severe and advanced forms of Parkinson disease.

Understanding which nerve cells in the brain are involved in these symptoms of Parkinson disease might provide researchers with new therapeutic targets. In this context, a team of researchers, led by Chantal Franηois and Etienne Hirsch, at Universitι Pierre et Marie Curie -- Paris 6, France, has now determined that the presence of gait disorders in patients with Parkinson disease and in aged monkeys with Parkinson-like disease was associated with loss of nerve cells that produce the neurotransmitter acetylcholine in a region of the brain known as the pedunculopontine nucleus (PPN).

Consistent with this, disrupting these nerve cells induced gait and postural deficits in monkeys. The authors therefore suggest that targeting acetylcholine-producing nerve cells in the PPN might provide a way to alleviate the gait disorders and falls experienced by individuals with Parkinson disease.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carine Karachi et al. Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease. Journal of Clinical Investigation, DOI: 10.1172/JCI42642

Cite This Page:

Journal of Clinical Investigation. "Parkinson's: New clues to alleviating gait disorders and falls." ScienceDaily. ScienceDaily, 26 July 2010. <www.sciencedaily.com/releases/2010/07/100712121828.htm>.
Journal of Clinical Investigation. (2010, July 26). Parkinson's: New clues to alleviating gait disorders and falls. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2010/07/100712121828.htm
Journal of Clinical Investigation. "Parkinson's: New clues to alleviating gait disorders and falls." ScienceDaily. www.sciencedaily.com/releases/2010/07/100712121828.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Cases Keep Coming for Monrovia's Island Hospital

Ebola Cases Keep Coming for Monrovia's Island Hospital

AFP (Oct. 1, 2014) — A look inside Monrovia's Island Hospital, a key treatment centre in the fight against Ebola in Liberia's capital city. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Ebola Puts Stress on Liberian Health Workers

Ebola Puts Stress on Liberian Health Workers

AP (Oct. 1, 2014) — The Ebola outbreak is putting stress on first responders in Liberia. Ambulance drivers say they are struggling with chronic shortages of safety equipment and patients who don't want to go to the hospital. (Oct. 1) Video provided by AP
Powered by NewsLook.com
Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Doctors Reassure Public Ebola Patient Won't Cause Outbreak

Newsy (Sep. 30, 2014) — After the announcement that the first U.S. patient had been diagnosed with Ebola, doctors were quick to say a U.S. outbreak is highly unlikely. Video provided by Newsy
Powered by NewsLook.com
TX Hospital Confirms Patient Admitted With Ebola

TX Hospital Confirms Patient Admitted With Ebola

AP (Sep. 30, 2014) — Medical officials from Texas Health Presbyterian Hospital confirm they are treating a patient with the Ebola virus, the first case found in the US. (Sept. 30 Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins