Featured Research

from universities, journals, and other organizations

Parkinson's: New clues to alleviating gait disorders and falls

Date:
July 26, 2010
Source:
Journal of Clinical Investigation
Summary:
Drugs that target the mediator of nerve cell communication dopamine alleviate many of the symptoms of Parkinson's disease but not the gait disorders and falls that affect those with severe disease. New research indicates that drugs targeting nerve cells that communicate using the molecule acetylcholine in the PPN region of the brain might provide a way to alleviate these otherwise untreatable symptoms of Parkinson's disease.

Many of the symptoms of Parkinson disease can be alleviated with drugs that target dompamine, a chemical in the brain that is involved in nerve cell communication and therefore known as a neurotransmitter. However, such drugs do not improve the gait disorders and falls that commonly affect individuals with severe and advanced forms of Parkinson disease.

Related Articles


Understanding which nerve cells in the brain are involved in these symptoms of Parkinson disease might provide researchers with new therapeutic targets. In this context, a team of researchers, led by Chantal François and Etienne Hirsch, at Université Pierre et Marie Curie -- Paris 6, France, has now determined that the presence of gait disorders in patients with Parkinson disease and in aged monkeys with Parkinson-like disease was associated with loss of nerve cells that produce the neurotransmitter acetylcholine in a region of the brain known as the pedunculopontine nucleus (PPN).

Consistent with this, disrupting these nerve cells induced gait and postural deficits in monkeys. The authors therefore suggest that targeting acetylcholine-producing nerve cells in the PPN might provide a way to alleviate the gait disorders and falls experienced by individuals with Parkinson disease.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Carine Karachi et al. Cholinergic mesencephalic neurons are involved in gait and postural disorders in Parkinson disease. Journal of Clinical Investigation, DOI: 10.1172/JCI42642

Cite This Page:

Journal of Clinical Investigation. "Parkinson's: New clues to alleviating gait disorders and falls." ScienceDaily. ScienceDaily, 26 July 2010. <www.sciencedaily.com/releases/2010/07/100712121828.htm>.
Journal of Clinical Investigation. (2010, July 26). Parkinson's: New clues to alleviating gait disorders and falls. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2010/07/100712121828.htm
Journal of Clinical Investigation. "Parkinson's: New clues to alleviating gait disorders and falls." ScienceDaily. www.sciencedaily.com/releases/2010/07/100712121828.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Leaves Orphans Alone in Sierra Leone

Ebola Leaves Orphans Alone in Sierra Leone

AFP (Nov. 27, 2014) — The Ebola epidemic sweeping Sierra Leone is having a profound effect on the country's children, many of whom have been left without any family members to support them. Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Experimental Ebola Vaccine Shows Promise In Human Trial

Experimental Ebola Vaccine Shows Promise In Human Trial

Newsy (Nov. 27, 2014) — A recent test of a prototype Ebola vaccine generated an immune response to the disease in subjects. Video provided by Newsy
Powered by NewsLook.com
Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) — Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins