Featured Research

from universities, journals, and other organizations

New toxin may be key to MRSA severity

Date:
July 17, 2010
Source:
NIH/National Institute of Allergy and Infectious Diseases
Summary:
A research project to identify all the surface proteins of USA300 -- the most common community-associated strain of the methicillin-resistant form of the bacterium Staphylococcus aureus -- has resulted in the identification and isolation of a plentiful new toxin that laboratory studies indicate is a potent killer of human immune cells. Scientists say the toxin could be a key factor in the severity of MRSA infections in otherwise healthy people.

A research project to identify all the surface proteins of USA300—the most common community-associated strain of the methicillin-resistant form of the bacterium Staphylococcus aureus (MRSA)—has resulted in the identification and isolation of a plentiful new toxin that laboratory studies indicate is a potent killer of human immune cells. Scientists at the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, say the toxin could be a key factor in the severity of MRSA infections in otherwise healthy people.

Related Articles


The toxin, named LukGH, consists of two small proteins found on the surface of the bacteria and is secreted freely into the surrounding environment.

The scientists identified 113 proteins associated with the surface of USA300 and began to examine the role of the previously uncharacterized proteins. S. aureus surface proteins are key indicators of how the pathogen will respond to contact with immune system cells, such as neutrophils, which the body produces in large numbers to kill invading microbes. Some proteins can aggressively attack these immune cells, and the demise of the neutrophils ultimately enables the bacteria to replicate and thrive. When the LukGH toxin was removed from USA300, studies showed that the strain caused little to no damage to human neutrophils. With the toxin present, the bacteria began forming pores in neutrophils which eventually led to their destruction.

The scientists, including Frank DeLeo, Ph.D., Chief of the Laboratory of Human Bacterial Pathogenesis, say they do not know the full contribution of LukGH to the severity of MRSA infection. However, LukGH is the only MRSA toxin currently known to promote destruction of human neutrophils after the bacteria have been ingested by the immune cells designed to destroy them.

Using animal models of MRSA infection, the NIH team is continuing to study the role of LukGH in disease.


Story Source:

The above story is based on materials provided by NIH/National Institute of Allergy and Infectious Diseases. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ventura et al. Identification of a novel Staphylococcus aureus two-component leukotoxin using cell surface proteomics. PLoS ONE, 2010; 5 (7): e11634 DOI: 10.1371/journal.pone.0011634

Cite This Page:

NIH/National Institute of Allergy and Infectious Diseases. "New toxin may be key to MRSA severity." ScienceDaily. ScienceDaily, 17 July 2010. <www.sciencedaily.com/releases/2010/07/100716222228.htm>.
NIH/National Institute of Allergy and Infectious Diseases. (2010, July 17). New toxin may be key to MRSA severity. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/2010/07/100716222228.htm
NIH/National Institute of Allergy and Infectious Diseases. "New toxin may be key to MRSA severity." ScienceDaily. www.sciencedaily.com/releases/2010/07/100716222228.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins