Featured Research

from universities, journals, and other organizations

Middle school students co-author research on enzyme for activating promising disease-fighters

Date:
July 28, 2010
Source:
American Chemical Society
Summary:
Two middle school students from Wisconsin joined a team of scientists who are reporting the first glimpse of the innermost structure of a key bacterial enzyme. It helps activate certain antibiotics and anti-cancer agents so that those substances do their job.

These computerized images show the innermost structure of a key bacterial enzyme that helps activate certain antibiotics and anti-cancer agents.
Credit: American Chemical Society

Two middle school students from Wisconsin joined a team of scientists who are reporting the first glimpse of the innermost structure of a key bacterial enzyme. It helps activate certain antibiotics and anti-cancer agents so that those substances do their job.

Their study appears in ACS' weekly journal Biochemistry.

The student co-authors of the study are from Edgewood Campus Middle School in Madison and participated in Project CRYSTAL, a special program that provides middle school students with hands-on laboratory experience.

In the report, study leader Hazel Holden and colleagues note intense scientific interest in a chemical process called methylation, which increases the activity of DNA, proteins, and other substances in the body by transferring methyl (CH3) groups to them. Special enzymes called methyltransferases make methylation possible, and these proteins are very important in a myriad of key biological processes.

Holden and colleagues studied a bacterial methyltransferase involved in the production of tetronitrose, a component of the promising anti-cancer agent, tetrocarcin, and the antibiotic kijanimicin. The methyltransferase seems to play a key role in activating these disease-fighters. The scientists identified the 3D structure of this methyltransferase, a key step in determining how it works and how it might be modified for potential use in medicine.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nathan A. Bruender, James B. Thoden, Manpreet Kaur, Marie K. Avey, Hazel M. Holden. Molecular Architecture of a C-3'-Methyltransferase Involved in the Biosynthesis of D-Tetronitrose. Biochemistry, 2010: 100622125956005 DOI: 10.1021/bi100782b

Cite This Page:

American Chemical Society. "Middle school students co-author research on enzyme for activating promising disease-fighters." ScienceDaily. ScienceDaily, 28 July 2010. <www.sciencedaily.com/releases/2010/07/100728121422.htm>.
American Chemical Society. (2010, July 28). Middle school students co-author research on enzyme for activating promising disease-fighters. ScienceDaily. Retrieved August 31, 2014 from www.sciencedaily.com/releases/2010/07/100728121422.htm
American Chemical Society. "Middle school students co-author research on enzyme for activating promising disease-fighters." ScienceDaily. www.sciencedaily.com/releases/2010/07/100728121422.htm (accessed August 31, 2014).

Share This




More Plants & Animals News

Sunday, August 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Experimental Ebola Drug ZMapp Cures Lab Monkeys Of Disease

Newsy (Aug. 29, 2014) In a new study, a promising experimental treatment for Ebola managed to cure a group of infected macaque monkeys. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Raw: Australian Sheep Gets Long Overdue Haircut

Raw: Australian Sheep Gets Long Overdue Haircut

AP (Aug. 28, 2014) Hoping to break the record for world's wooliest, Shaun the sheep came up 10 pounds shy with his fleece weighing over 50 pounds after being shorn for the first time in years. (Aug. 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins