July 30, 2010 Mushrooms are among the many foods thought to play an important role in keeping the immune system healthy. Now, Agricultural Research Service (ARS)-funded scientists have conducted an animal-model and cell-culture study showing that white button mushrooms enhanced the activity of critical cells in the body's immune system.
In the United States, white button mushrooms represent 90 percent of the total mushrooms consumed.
The study was conducted at the Jean Mayer USDA Human Nutrition Research Center on Aging (HNRCA) at Tufts University by center director Simin Meydani, colleague Dayong Wu, and others.
The results suggest that white button mushrooms may promote immune function by increasing production of antiviral and other proteins that are released by cells while seeking to protect and repair tissue.
Wu and co-investigators are with the HNRCA Nutritional Immunology Laboratory in Boston, Mass. The study's cell-culture phase showed that white button mushrooms enhanced the maturity of immune system cells called "dendritic cells," from bone marrow.
Dendritic cells can make T cells -- important white blood cells that can recognize and eventually deactivate or destroy antigens on invading microbes.
When immune system cells are exposed to disease-causing pathogens, such as bacteria, the body begins to increase the number and function of immune system cells, according to Meydani. People need an adequate supply of nutrients to produce an adequate defense against the pathogen. The key is to prevent deficiencies that can compromise the immune system.
The study appears in a 2008 issue of Journal of Nutrition.
Read more about this and other research related to improving health through nutrition in the July 2010 issue of Agricultural Research magazine, available online at: http://www.ars.usda.gov/is/AR/archive/jul10/immunity0710.htm.
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- Zhihong Ren, Zhuyan Guo, Simin Nikbin Meydani and Dayong Wu. White Button Mushroom Enhances Maturation of Bone Marrow-Derived Dendritic Cells and Their Antigen Presenting Function in Mice. Journal of Nutrition, 2008; 138: 544-550 [link]
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