Featured Research

from universities, journals, and other organizations

The taste of quinine: It's in your bitter genes

Date:
August 2, 2010
Source:
Monell Chemical Senses Center
Summary:
Scientists report that individual differences in how people experience quinine's bitterness are related to underlying differences in their genes.

Some people find quinine to be bitter while others can drink it like water. Now, scientists from the Monell Center and collaborators report that individual differences in how people experience quinine's bitterness are related to underlying differences in their genes.

Related Articles


The findings, published online in the journal Human Molecular Genetics, demonstrate that genetic variation in regions of DNA that encode bitter taste receptors predicts a person's perception of bitterness from quinine.

Quinine is an anti-malarial drug that comes from the bark of the cinchona tree. Very small amounts are used to flavor tonic water.

"This study teaches us that naturally occurring medicinal compounds taste differently to people based on variations in and near a bitter receptor gene," said lead author Danielle R. Reed, PhD, a behavioral geneticist at Monell.

It was previously known that people vary in their ability to taste synthetic bitter compounds based on their taste receptor DNA. However, not all bitter compounds are detected by the same receptors and it was not known if bitter perception of naturally-occurring medicines like quinine also was affected by genetic makeup.

In the study, 1457 twins and their siblings tasted quinine and rated its intensity. They also provided DNA samples.

The researchers then evaluated over two million places in the human genome to see whether people who were more similar in their perception of quinine also shared the same pattern of DNA.

They identified a region on chromosome 12 that was both near a bitter receptor and also associated with perception of quinine's bitterness.

Testing a separate set of 73 twins, Reed and her collaborators confirmed that DNA changes within a gene coding for bitter receptors were associated with how intensely people perceived the bitterness of quinine.

"Depending on differences in human DNA, some people find quinine to be more bitter than others do," said Reed.

In addition to being located in the mouth, bitter receptors also are found in the gut. It is possible that people who are insensitive to quinine's taste might also absorb or metabolize it differently.

Noting that both the taste perception of a compound and its pharmacological properties might be conveyed via the same receptors, Reed speculates, "We wonder whether people who are less sensitive to the taste of some bitter medicines might get less pharmacological benefit from them."

Future studies will seek to determine whether people who perceive quinine as more bitter are also more likely to benefit from quinine's anti-malarial actions.

Also contributing to the study were Paul Breslin and Fujiko Duke from Monell and Gu Zhu, Anjali Henders, Megan Campbell, Grant Montgomery, Sarah Medland, Nicholas Martin, and Margaret Wright from Queensland Institute of Medical Research, Australia. The research was supported by the National Institute on Deafness and Other Communication Disorders, National Institutes of Health, the National Health and Medical Research Council, and the Australian Research Council.


Story Source:

The above story is based on materials provided by Monell Chemical Senses Center. Note: Materials may be edited for content and length.


Cite This Page:

Monell Chemical Senses Center. "The taste of quinine: It's in your bitter genes." ScienceDaily. ScienceDaily, 2 August 2010. <www.sciencedaily.com/releases/2010/08/100802125848.htm>.
Monell Chemical Senses Center. (2010, August 2). The taste of quinine: It's in your bitter genes. ScienceDaily. Retrieved October 26, 2014 from www.sciencedaily.com/releases/2010/08/100802125848.htm
Monell Chemical Senses Center. "The taste of quinine: It's in your bitter genes." ScienceDaily. www.sciencedaily.com/releases/2010/08/100802125848.htm (accessed October 26, 2014).

Share This



More Health & Medicine News

Sunday, October 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Texas Nurse Nina Pham Cured of Ebola

Texas Nurse Nina Pham Cured of Ebola

AFP (Oct. 25, 2014) — An American nurse who contracted Ebola while caring for a Liberian patient in Texas has been declared free of the virus and will leave the hospital. Duration: 01:01 Video provided by AFP
Powered by NewsLook.com
Toxin-Packed Stem Cells Used To Kill Cancer

Toxin-Packed Stem Cells Used To Kill Cancer

Newsy (Oct. 25, 2014) — A Harvard University Research Team created genetically engineered stem cells that are able to kill cancer cells, while leaving other cells unharmed. Video provided by Newsy
Powered by NewsLook.com
IKEA Desk Converts From Standing to Sitting With One Button

IKEA Desk Converts From Standing to Sitting With One Button

Buzz60 (Oct. 24, 2014) — IKEA is out with a new convertible desk that can convert from a sitting desk to a standing one with just the push of a button. Jen Markham explains. Video provided by Buzz60
Powered by NewsLook.com
Ebola Protective Suits Being Made in China

Ebola Protective Suits Being Made in China

AFP (Oct. 24, 2014) — A factory in China is busy making Ebola protective suits for healthcare workers and others fighting the spread of the virus. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins