Featured Research

from universities, journals, and other organizations

Potential key regulator in battle to target inflammatory bowel disease identified

Date:
August 3, 2010
Source:
UCD Conway Institute of Biomolecular & Biomedical Research
Summary:
Research into inflammatory bowel disease has identified a key regulator involved in maintaining the functional integrity of the gut lining. The findings provide information that may be important in developing a new therapeutic approach to the treatment of the disease.

Research into inflammatory bowel disease (IBD) led by UCD Conway Institute scientists with national and international collaborators has identified a key regulator involved in maintaining the functional integrity of the gut lining. The findings, published recently in the scientific journal, Gastroenterology, provide information that may be important in developing a new therapeutic approach to the treatment of the disease.

The underlying genetic or environmental causes of inflammatory bowel disease remain largely unknown. However, the major problem associated with this chronic condition is that the lining of the gut becomes leaky, allowing material from the lumen of the intestine to pass through this barrier and trigger an inflammatory response.

The intestinal barrier works by maintaining a delicate balance between the proliferation and death of epithelial cells at the surface of the barrier. If the balances tips so that more cells die than grow, as is the case in IBD, the barrier is no longer intact and cannot function properly.

This latest research led by Conway Fellow, Professor Cormac Taylor has shown that in the absence of an oxygen-sensing enzyme, prolyl hydroxylase 1 (PHD1), epithelial cell death is reduced and the intestinal barrier function is enhanced. Therefore, PHD1 may be a useful target for pharmacologic inhibition in IBD.

The team, which includes scientists from the University of Leuven, Belgium; University of Heidleberg, Germany; University College London and the Institute of Molecular Medicine, Trinity College Dublin, propose that by delaying or suppressing epithelial cell death, the gut lining would be given time to heal and the integrity of the intestinal barrier could be restored.

Commenting on the research, Professor Taylor said "Inflammatory bowel disease is a condition in need of new and improved therapeutic options. Our current results indicate that targeting the PHD1 enzyme may represent one such approach."

In separate but related research, the Taylor group collaborate with the Irish biopharmaceutical development company, Sigmoid Pharma to facilitate targeted drug delivery to specific areas of the gut as part of a new therapeutic approach to the treatment of IBD.

Science Foundation Ireland and the German Research Foundation funded the research by this group.


Story Source:

The above story is based on materials provided by UCD Conway Institute of Biomolecular & Biomedical Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. Murtaza M. Tambuwala, Eoin P. Cummins, Colin R. Lenihan, Judith Kiss, Markus Stauch, Carsten C. Scholz, Peter Fraisl, Felix Lasitschka, Martin Mollenhauer, Sean P. Saunders. Loss of prolyl hydroxylase-1 protects against colitis through reduced epithelial cell apoptosis and increased barrier function. Gastroenterology, 2010; DOI: 10.1053/j.gastro.2010.06.068

Cite This Page:

UCD Conway Institute of Biomolecular & Biomedical Research. "Potential key regulator in battle to target inflammatory bowel disease identified." ScienceDaily. ScienceDaily, 3 August 2010. <www.sciencedaily.com/releases/2010/08/100803072717.htm>.
UCD Conway Institute of Biomolecular & Biomedical Research. (2010, August 3). Potential key regulator in battle to target inflammatory bowel disease identified. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/2010/08/100803072717.htm
UCD Conway Institute of Biomolecular & Biomedical Research. "Potential key regulator in battle to target inflammatory bowel disease identified." ScienceDaily. www.sciencedaily.com/releases/2010/08/100803072717.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins