Featured Research

from universities, journals, and other organizations

How cells make specific interactions during development

Date:
August 6, 2010
Source:
University of Iowa - Health Science
Summary:
Researchers have shed new light on how cells make specific interactions during development -- in the hope of one day learning more about human developmental disorders.

Two University of Iowa biologists have published a paper on how cells make specific interactions during development -- in the hope of one day learning more about human developmental disorders -- in the Aug. 2 issue of the journal Proceedings of the National Academy of Sciences.

Dietmar Schreiner, postdoctoral researcher, and Joshua A. Weiner, assistant professor of biology in the UI College of Liberal Arts and Sciences Department of Biology, write on the subject of cell adhesion. Cell adhesion is the way in which one cell binds itself to another cell by using specific molecules, one large family of which is known as the cadherins.

The researchers found that when a specific kind of cadherin molecule -- the 22-member gamma-protocadherin family -- are involved in linking adjacent cells together, it exponentially expands the molecular diversity and specificity with which cells can interact.

"We already knew that with 22 different members, the gamma-protocadherin family was diverse, and we had already shown that they are critical for the developing nervous system," said Weiner. "But what Dietmar was able to do here, for the first time, is develop a quantitative method to determine how each gamma protocadherin protein mediates cell-cell adhesion, and which family members can interact with each other. He finds that the proteins seem to freely associate in groups of four at the surface of each cell, but that in order for another cell to bind, it must have pretty much the exact same group of four. What this means is that, if you figure out all the possible combinations of gamma-protocadherins, this group of proteins can form over 200,000 distinct adhesive surfaces."

One implication of the work is that scientists have gained a better understanding of the ways in which cell linkages, including those made during the formation and modification of synapses, the points of communication between nerve cells, might go awry in a number of developmental disorders such as autism and mental retardation, as well as how brain circuits assemble correctly during normal development.

In the future, the researchers plan to study directy how the differential interactions mediated by the many combinations of gamma-protocadherins affects the formation of synapses in the developing brain, and what adhesion mediated by these proteins "tells" a young neuron to do.

Their work was funded by a grant from The National Institutes of Health.


Story Source:

The above story is based on materials provided by University of Iowa - Health Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dietmar Schreiner, Joshua A. Weiner. Combinatorial homophilic interaction between %u03B3-protocadherin multimers greatly expands the molecular diversity of cell adhesion. Proceedings of the National Academy of Sciences, 2010; DOI: 10.1073/pnas.1004526107

Cite This Page:

University of Iowa - Health Science. "How cells make specific interactions during development." ScienceDaily. ScienceDaily, 6 August 2010. <www.sciencedaily.com/releases/2010/08/100803152813.htm>.
University of Iowa - Health Science. (2010, August 6). How cells make specific interactions during development. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2010/08/100803152813.htm
University of Iowa - Health Science. "How cells make specific interactions during development." ScienceDaily. www.sciencedaily.com/releases/2010/08/100803152813.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins