Featured Research

from universities, journals, and other organizations

Genetic variation linked to lupus in Asian men identified

Date:
August 24, 2010
Source:
University of California - Los Angeles
Summary:
Researchers have found that a variation in a gene on the sex chromosome X may enhance an immune response that leads to lupus in men.

Genes reside along long chains of DNA called chromosomes. UCLA researchers have found that a variation in a gene on the sex chromosome X may enhance an immune response that leads to lupus in men.

Systemic lupus erythematosus (SLE) is an autoimmune disease that predominantly affects women. Interestingly, researchers found that although the variation occurred in a gene on the X, or female, chromosome, its influence was stronger in men than in women. Humans hold two sex chromosomes -- men have an X and Y, while women have two Xs. Previous studies have shown that genetic variations on the X chromosome contribute to the development of lupus.

In this study, Betty P. Tsao, Ph.D., a professor of medicine in the Division of Rheumatology at the David Geffen School of Medicine at UCLA, and colleagues found that certain common variations of DNA sequences within a specific X-linked gene triggered a stronger response in the immune system, increasing the risk of developing lupus, especially in men.

This study was part of an international effort to study the genetics of lupus in broader ethnic groups. Researchers genotyped 9,274 Eastern Asians individuals, including those with lupus and healthy controls. The stronger genetic effects were seen in men, compared with women, and especially in Chinese and Japanese men. Further study will look at other ethnicities.

Researchers say the finding will lead to greater understanding of the development of lupus and to further exploration of the sex-specific genetic contributions of the disease, which could result in more targeted therapies.

The study was funded by the Lupus Research Institute, a nonprofit association dedicated to supporting innovative research in lupus.

The research appears in the Aug. 23 online edition of the journal Proceedings of the National Academy of Sciences (PNAS).


Story Source:

The above story is based on materials provided by University of California - Los Angeles. The original article was written by Rachel Champeau. Note: Materials may be edited for content and length.


Journal Reference:

  1. Nan Shen, Qiong Fu, Yun Deng, Xiaoxia Qian, Jian Zhao, Kenneth M. Kaufman, Yee Ling Wu, C. Yung Yu, Yuanjia Tang, Ji-Yih Chen, Wanling Yang, Maida Wong, Aya Kawasaki, Naoyuki Tsuchiya, Takayuki Sumida, Yasushi Kawaguchi, Hwee Siew Howe, Mo Yin Mok, So-Young Bang, Fei-Lan Liu, Deh-Ming Chang, Yoshinari Takasaki, Hiroshi Hashimoto, John B. Harley, Joel M. Guthridge, Jennifer M. Grossman, Rita M. Cantor, Yeong Wook Song, Sang-Cheol Bae, Shunle Chen, Bevra H. Hahn, Yu Lung Lau, and Betty P. Tsao. Sex-specific association of X-linked Toll-like receptor 7 (TLR7) with male systemic lupus erythematosus. Proceedings of the National Academy of Sciences, 2010; DOI: 10.1073/pnas.1001337107

Cite This Page:

University of California - Los Angeles. "Genetic variation linked to lupus in Asian men identified." ScienceDaily. ScienceDaily, 24 August 2010. <www.sciencedaily.com/releases/2010/08/100823162324.htm>.
University of California - Los Angeles. (2010, August 24). Genetic variation linked to lupus in Asian men identified. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2010/08/100823162324.htm
University of California - Los Angeles. "Genetic variation linked to lupus in Asian men identified." ScienceDaily. www.sciencedaily.com/releases/2010/08/100823162324.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins