Featured Research

from universities, journals, and other organizations

Lipid peroxides: More sophisticated than their reputation

Date:
August 24, 2010
Source:
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health
Summary:
Accumulation of lipid peroxides in the cell are associated with diseases and cellular stress. In a new study, researchers show that lipid peroxides also play an important, yet unrecognized, role in the regulation of receptor tyrosine kinases.

Accumulation of lipid peroxides in the cell are associated with diseases and cellular stress. In the current issue of Proceedings of the National Academy of Sciences, researchers at Helmholtz Zentrum München and the Swedish medical university Karolinska Institutet show that lipid peroxides also play an important, yet-unrecognized role in the regulation of receptor tyrosine kinases.

Neurodegenerative Diseases (DZNE) and a research group at Karolinska Institutet in Stockholm, Sweden, researchers have now discovered that lipid peroxides play a specific physiological role in the cell. Prior to this study, scientists had already established that accumulation of lipid peroxides indicate cell stress. Lipid peroxides have further been shown to be very potent inducers of cell death.

The results of this study now demonstrate that chemically modified (oxidized) lipids temporarily inactivate protein tyrosine phosphatases. These in turn regulate the cellular communication of receptor tyrosine kinases (RTK). This finding is of central importance because aberrant activation of the receptor tyrosine kinases contributes to many diseases, including cancer. Until now, only hydrogen peroxide was known to oxidize and inactivate protein tyrosine phosphatases and thus to have a regulating effect on kinases.

"We were able to show that lipid peroxides are 100-1000 times more effective than hydrogen peroxide," said Dr. Marcus Conrad, lead authors of the publication, who has since moved from Helmholtz Zentrum München to the German Center for Neurodegenerative Disease. Dr. Arne Östman and Åsa Sandin from the Karolinska Institutet added: "It will be very interesting to see if lipid peroxides contribute to the activation of tyrosine kinases in cancer and other diseases, e.g. diabetes and Alzheimer's disease."

Background

Lipid peroxides are chemically modified lipids or fatty acids, which, among other things, indicate cellular stress. In high concentrations they can trigger cell death. Elevated concentrations of lipid peroxides are often found in patients with common diseases such as atherosclerosis, diabetes, cancer or neurodegenerative diseases including Parkinson's and Alzheimer's disease.

Receptor tyrosine kinases (RTK) and protein tyrosine phosphatases have an important function in the regulation of cell growth and division. Over-active receptor tyrosine kinases play a key role in the etiology of cancer. A frequent cause of breast cancer, for instance, is a malfunction of the receptor tyrosine kinase HER-2 (human epidermal growth factor receptor 2). In healthy tissues and cells receptor tyrosine kinases are precisely regulated by protein tyrosine phosphatases.


Story Source:

The above story is based on materials provided by Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Conrad, A. Sandin, H. Forster, A. Seiler, J. Frijhoff, M. Dagnell, G. W. Bornkamm, O. Radmark, R. Hooft van Huijsduijnen, P. Aspenstrom, F. Bohmer, A. Ostman. 12/15-lipoxygenase-derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases. Proceedings of the National Academy of Sciences, 2010; DOI: 10.1073/pnas.1007909107

Cite This Page:

Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Lipid peroxides: More sophisticated than their reputation." ScienceDaily. ScienceDaily, 24 August 2010. <www.sciencedaily.com/releases/2010/08/100824082220.htm>.
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. (2010, August 24). Lipid peroxides: More sophisticated than their reputation. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2010/08/100824082220.htm
Helmholtz Zentrum Muenchen - German Research Centre for Environmental Health. "Lipid peroxides: More sophisticated than their reputation." ScienceDaily. www.sciencedaily.com/releases/2010/08/100824082220.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) — Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
Study Says Most Crime Not Linked To Mental Illness

Study Says Most Crime Not Linked To Mental Illness

Newsy (Apr. 22, 2014) — A new study finds most crimes committed by people with mental illness are not caused by symptoms of their illness or disorder. Video provided by Newsy
Powered by NewsLook.com
Hagel Gets Preview of New High-Tech Projects

Hagel Gets Preview of New High-Tech Projects

AP (Apr. 22, 2014) — Defense Secretary Chuck Hagel is given hands-on demonstrations Tuesday of some of the newest research from DARPA _ the military's Defense Advanced Research Projects Agency program. (April 22) Video provided by AP
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) — NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins