Featured Research

from universities, journals, and other organizations

New pump created for microneedle drug-delivery patch

Date:
September 5, 2010
Source:
Purdue University
Summary:
Researchers have developed a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches.

Purdue doctoral student Charilaos Mousoulis demonstrates a prototype pump for drug-delivery patches that might use arrays of microneedles to deliver a wider range of medications than now possible with conventional patches.
Credit: Purdue University photo/Birck Nanotechnology Center

Purdue University researchers have developed a new type of pump for drug-delivery patches that might use arrays of "microneedles" to deliver a wider range of medications than now possible with conventional patches.

Related Articles


The current "transdermal" patches are limited to delivering drugs that, like nicotine, are made of small hydrophobic molecules that can be absorbed through the skin, said Babak Ziaie, a professor of electrical and computer engineering and biomedical engineering.

"There are only a handful of drugs that currently can be administered with patches," he said. "Most new drugs are large molecules that won't go through the skin. And a lot of drugs, such as those for treating cancer and autoimmune disorders, you can't take orally because they aren't absorbed into the blood system through the digestive tract."

Patches that used arrays of tiny microneedles could deliver a multitude of drugs, and the needles do not cause pain because they barely penetrate the skin, he said.

"It's like a bandage -- you would use it and discard," Ziaie said.

The patches require a pump to push the drugs through the narrow needles, which have a diameter of about 20 microns, or roughly one-fourth as wide as a human hair. However, pumps on the market are too complex for patches, he said.

"We have developed a simple pump that's activated by touch from the heat of your finger and requires no battery," Ziaie said.

The pump contains a liquid that boils at body temperature so that the heat from a finger's touch causes it to rapidly turn to a vapor, exerting enough pressure to force drugs through the microneedles.

"It takes 20 to 30 seconds," Ziaie said.

The liquid is contained in a pouch separated from the drug by a thin membrane made of a rubberlike polymer, called polydimethylsiloxane, which is used as diaphragms in pumps.

Research findings are detailed in a paper being presented during the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences on Oct. 3-7 at University of Groningen in The Netherlands. The paper was written by electrical and computer engineering doctoral students Charilaos Mousoulis and Manuel Ochoa and Ziaie.

Researchers have filed an application for a provisional patent on the device.

Ziaie has tested prototypes with liquids called fluorocarbons, which are used as refrigerants and also in semiconductor manufacturing.

"You need a relatively large force, a few pounds per square inch, to push medications through the microneedles and into the skin," Ziaie said. "It's very difficult to find a miniature pump that can provide that much force."

Findings indicate prototypes using the fluorocarbon HFE-7000 exerted 4.87 psi and another fluorocarbon, FC-3284, exerted 2.24 psi.

The work has been supported with funding from the National Science Foundation. Future research may include work to try the pump with microneedles.


Story Source:

The above story is based on materials provided by Purdue University. The original article was written by Emil Venere. Note: Materials may be edited for content and length.


Cite This Page:

Purdue University. "New pump created for microneedle drug-delivery patch." ScienceDaily. ScienceDaily, 5 September 2010. <www.sciencedaily.com/releases/2010/09/100901121757.htm>.
Purdue University. (2010, September 5). New pump created for microneedle drug-delivery patch. ScienceDaily. Retrieved March 30, 2015 from www.sciencedaily.com/releases/2010/09/100901121757.htm
Purdue University. "New pump created for microneedle drug-delivery patch." ScienceDaily. www.sciencedaily.com/releases/2010/09/100901121757.htm (accessed March 30, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins