Featured Research

from universities, journals, and other organizations

Cells can eat parts of themselves, with help from one protein

Date:
September 7, 2010
Source:
Rockefeller University Press
Summary:
Like some people, cells eat when they are under pressure -- but they consume parts of themselves. A multi-function protein helps control this form of cannibalism, according to a new article.

Sites of autophagy (green) are reduced in cells lacking HMGB1 (left) compared with control cells (right).
Credit: Tang, D., et al. 2010. J. Cell Biol. doi:10.1083/jcb.200911078.

Like some people, cells eat when they are under pressure -- but they consume parts of themselves. A multi-function protein helps control this form of cannibalism, according to a study in the September 6 issue of the Journal of Cell Biology.

Cells often respond to hunger or stress by digesting some of their contents. The process, known as autophagy, helps free nutrients and clean up cytoplasmic trash such as worn-out organelles and misshapen proteins. A team led by researchers at the University of Pittsburgh Cancer Institute discovered a link between this form of cellular recycling and the protein HMGB1. The team showed HMGB1 to be a critical pro-autophagic protein that enhances cell survival and limits programmed cell death.

The findings suggests that blocking HMGB1 could benefit cancer patients, since tumor cells often rev up autophagy to withstand chemotherapy, immunotherapy, and radiation treatment.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mitch Leslie. With HMGB1's help, cells dine in. The Journal of Cell Biology, September 6, 2010; vol. 190 no. 5 708 DOI: 10.1083/jcb.1905iti3

Cite This Page:

Rockefeller University Press. "Cells can eat parts of themselves, with help from one protein." ScienceDaily. ScienceDaily, 7 September 2010. <www.sciencedaily.com/releases/2010/09/100906141215.htm>.
Rockefeller University Press. (2010, September 7). Cells can eat parts of themselves, with help from one protein. ScienceDaily. Retrieved July 23, 2014 from www.sciencedaily.com/releases/2010/09/100906141215.htm
Rockefeller University Press. "Cells can eat parts of themselves, with help from one protein." ScienceDaily. www.sciencedaily.com/releases/2010/09/100906141215.htm (accessed July 23, 2014).

Share This




More Plants & Animals News

Wednesday, July 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Stone Fruit Listeria Scare Causes Sweeping Recall

Stone Fruit Listeria Scare Causes Sweeping Recall

Newsy (July 22, 2014) The Wawona Packing Company has issued a voluntary recall on the stone fruit it distributes due to a possible Listeria outbreak. Video provided by Newsy
Powered by NewsLook.com
Michigan Plant's Goal: Flower and Die

Michigan Plant's Goal: Flower and Die

AP (July 22, 2014) An 80-year-old agave plant, which is blooming for the first and only time at a University of Michigan conservatory, will die when it's done (July 22) Video provided by AP
Powered by NewsLook.com
Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Huge Schizophrenia Study Finds Dozens Of New Genetic Causes

Newsy (July 22, 2014) The 83 new genetic markers could open dozens of new avenues for schizophrenia treatment research. Video provided by Newsy
Powered by NewsLook.com
CDC Head Concerned About a Post-Antibiotic Era

CDC Head Concerned About a Post-Antibiotic Era

AP (July 22, 2014) Sounding alarms about the growing threat of antibiotic resistance, CDC Director Tom Frieden warned Tuesday if the global community does not confront the problem soon, the world will be living in a devastating post-antibiotic era. (July 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins