Featured Research

from universities, journals, and other organizations

New class of peptides may protect against septic shock

Date:
September 9, 2010
Source:
American Society for Microbiology
Summary:
A new class of peptides may neutralize the endotoxin that causes sepsis, offering a new therapeutic strategy against an often lethal systemic bacterial infection.

A new class of peptides may neutralize the endotoxin that causes sepsis, offering a new therapeutic strategy against an often lethal systemic bacterial infection.

The researchers from Germany and Spain detail their findings in the September 2010 issue of the journal Antimicrobial Agents and Chemotherapy.

Septic shock, caused by systemic bacterial infections, kills more than 200,000 people each year in the U.S. alone despite intensive antibiotic treatment. Researchers are now looking to other resources such as natural proteins and peptides to neutralize the bacterial lipopolysaccharide (LPS) or endotoxin that causes sepsis, however, prior studies required such high peptide/LPS ratios that the peptide concentrations were deemed too toxic for human use.

Here, researchers designed a completely new class of peptides, synthetic anti-LPS peptides (SALPs), and preclinical studies in a mouse model showed high LPS neutralizing activity and significant protection against septic shock. Additionally, low toxicity levels potentially safe for humans were observed.

"Our results delineate a novel therapeutic strategy for the clinical management of patients with septic shock," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. T. Gutsmann, I. Razquin-Olazaran, I. Kowalski, Y. Kaconis, J. Howe, R. Bartels, M. Hornef, T. Schurholz, M. Rossle, S. Sanchez-Gomez, I. Moriyon, G. Martinez de Tejada, K. Brandenburg. New Antiseptic Peptides To Protect against Endotoxin-Mediated Shock. Antimicrobial Agents and Chemotherapy, 2010; 54 (9): 3817 DOI: 10.1128/AAC.00534-10

Cite This Page:

American Society for Microbiology. "New class of peptides may protect against septic shock." ScienceDaily. ScienceDaily, 9 September 2010. <www.sciencedaily.com/releases/2010/09/100908104411.htm>.
American Society for Microbiology. (2010, September 9). New class of peptides may protect against septic shock. ScienceDaily. Retrieved October 19, 2014 from www.sciencedaily.com/releases/2010/09/100908104411.htm
American Society for Microbiology. "New class of peptides may protect against septic shock." ScienceDaily. www.sciencedaily.com/releases/2010/09/100908104411.htm (accessed October 19, 2014).

Share This



More Plants & Animals News

Sunday, October 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Rare Lion Cubs Make Debut at Belgrade Zoo

Raw: Rare Lion Cubs Make Debut at Belgrade Zoo

AP (Oct. 17, 2014) Two white lion cubs were born in Belgrade zoo three weeks ago. White lions are a rare mutation of a species found in South Africa and some cultures consider them divine. (Oct. 17) Video provided by AP
Powered by NewsLook.com
The Best Foods To Boost Your Mood

The Best Foods To Boost Your Mood

Buzz60 (Oct. 17, 2014) Feeling down? Reach for the refrigerator, not the medicine cabinet! TC Newman (@PurpleTCNewman) shares some of the best foods to boost your mood. Video provided by Buzz60
Powered by NewsLook.com
Sweet Times for Hard Cider Makers

Sweet Times for Hard Cider Makers

AP (Oct. 16, 2014) With hard cider making a hardcore comeback across the country, craft makers are trying to keep up with demand and apple growers are tapping a juicy new revenue stream. (Oct. 16) Video provided by AP
Powered by NewsLook.com
Meet Garfi the Angry Cat

Meet Garfi the Angry Cat

Buzz60 (Oct. 16, 2014) Garfi is one frowny, feisty feline - downright angry! Ko Im (@koimtv) introduces us to the latest animal celebrity taking over the Internet. You can follow more of Garfi's adventures on Twitter (@MeetGarfi) and Facebook (Garfi). Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins