Featured Research

from universities, journals, and other organizations

Research could improve detection of liver damage

Date:
September 18, 2010
Source:
University of Liverpool
Summary:
New research could lead to faster and more accurate diagnoses of liver damage. Scientists in the UK used paracetamol as the basis for the study: research indicates that paracetamol can place temporary stress on the liver in around a third of people who take a normal dose (4g per day) but the liver returns to normal when the drug has left the system.

Research at the University of Liverpool could lead to faster and more accurate diagnoses of liver damage.

Related Articles


The team used paracetamol as the basis for the study: research indicates that paracetamol can place temporary stress on the liver in around a third of people who take a normal dose (4g per day) but the liver returns to normal when the drug has left the system. Overdoses of the drug are a major cause of liver failure in both the UK and US.

Scientists have discovered that the presence of specific proteins in the blood are indicative of early liver cell damage and can determine the point at which cell death occurred, the type of cell death, and the extent of any damage. This could lead to liver damage being assessed faster and more accurately in the future -- information which could prove valuable when treating people following drug overdoses.

The current blood test used by clinicians to assess liver function simply indicates whether liver enzymes leaking from dying cells can be detected in the blood. The test is not always reliable because positive results are often, but not always, an indicator of serious underlying liver problems.

Scientists induced a mild paracetamol overdose in mice and discovered that proteins released by cells in the liver -- HMGB1 and keratin 18 -- provided a detailed picture of the level of cell damage. The release of HMGB1 was associated with necrosis -- a process in which a cell bursts and dies -- while the release of different types of keratin 18 was associated with both apoptosis -- a process of normal cell renewal -- and necrosis. This latter combination of both types of cell death is significantly less traumatic for the liver than necrosis alone in paracetamol overdose.

Pharmacologist Dr Dominic Williams, from the University's Medical Research Council Centre for Drug Safety Science, said: "The findings are significant because knowing how the cells die will allow development of medicines to help them survive, and may also distinguish patients who have severe injury and require intensive care from those who have mild injury.

"The research has implications for determining how much stress has been placed on the liver in patients who are worried about an accidental overdose, as well as the more serious overdose cases."

The research is published in Molecular Medicine.


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Cite This Page:

University of Liverpool. "Research could improve detection of liver damage." ScienceDaily. ScienceDaily, 18 September 2010. <www.sciencedaily.com/releases/2010/09/100917101811.htm>.
University of Liverpool. (2010, September 18). Research could improve detection of liver damage. ScienceDaily. Retrieved March 28, 2015 from www.sciencedaily.com/releases/2010/09/100917101811.htm
University of Liverpool. "Research could improve detection of liver damage." ScienceDaily. www.sciencedaily.com/releases/2010/09/100917101811.htm (accessed March 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, March 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) — A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) — The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) — In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins