Featured Research

from universities, journals, and other organizations

Research could improve detection of liver damage

Date:
September 18, 2010
Source:
University of Liverpool
Summary:
New research could lead to faster and more accurate diagnoses of liver damage. Scientists in the UK used paracetamol as the basis for the study: research indicates that paracetamol can place temporary stress on the liver in around a third of people who take a normal dose (4g per day) but the liver returns to normal when the drug has left the system.

Research at the University of Liverpool could lead to faster and more accurate diagnoses of liver damage.

Related Articles


The team used paracetamol as the basis for the study: research indicates that paracetamol can place temporary stress on the liver in around a third of people who take a normal dose (4g per day) but the liver returns to normal when the drug has left the system. Overdoses of the drug are a major cause of liver failure in both the UK and US.

Scientists have discovered that the presence of specific proteins in the blood are indicative of early liver cell damage and can determine the point at which cell death occurred, the type of cell death, and the extent of any damage. This could lead to liver damage being assessed faster and more accurately in the future -- information which could prove valuable when treating people following drug overdoses.

The current blood test used by clinicians to assess liver function simply indicates whether liver enzymes leaking from dying cells can be detected in the blood. The test is not always reliable because positive results are often, but not always, an indicator of serious underlying liver problems.

Scientists induced a mild paracetamol overdose in mice and discovered that proteins released by cells in the liver -- HMGB1 and keratin 18 -- provided a detailed picture of the level of cell damage. The release of HMGB1 was associated with necrosis -- a process in which a cell bursts and dies -- while the release of different types of keratin 18 was associated with both apoptosis -- a process of normal cell renewal -- and necrosis. This latter combination of both types of cell death is significantly less traumatic for the liver than necrosis alone in paracetamol overdose.

Pharmacologist Dr Dominic Williams, from the University's Medical Research Council Centre for Drug Safety Science, said: "The findings are significant because knowing how the cells die will allow development of medicines to help them survive, and may also distinguish patients who have severe injury and require intensive care from those who have mild injury.

"The research has implications for determining how much stress has been placed on the liver in patients who are worried about an accidental overdose, as well as the more serious overdose cases."

The research is published in Molecular Medicine.


Story Source:

The above story is based on materials provided by University of Liverpool. Note: Materials may be edited for content and length.


Cite This Page:

University of Liverpool. "Research could improve detection of liver damage." ScienceDaily. ScienceDaily, 18 September 2010. <www.sciencedaily.com/releases/2010/09/100917101811.htm>.
University of Liverpool. (2010, September 18). Research could improve detection of liver damage. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2010/09/100917101811.htm
University of Liverpool. "Research could improve detection of liver damage." ScienceDaily. www.sciencedaily.com/releases/2010/09/100917101811.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins