Featured Research

from universities, journals, and other organizations

Botulinum toxin may offer temporary drooling relief in children with neurological disorders

Date:
September 24, 2010
Source:
JAMA and Archives Journals
Summary:
Botulinum toxin treatment appears to offer a temporary, short-term solution to relieve drooling in children diagnosed with certain neurological disorders, according to a new study.

Botulinum toxin treatment appears to offer a temporary, short-term solution to relieve drooling in children diagnosed with certain neurological disorders, according to a report in the September issue of Archives of Otolaryngology -- Head & Neck Surgery, one of the JAMA/Archives journals.

Related Articles


"Recent estimates suggest a prevalence of [drooling in] nearly 60 percent in children in special care school, of which 33 percent could be classified as severe," the authors write as background in the article. "Depending on the associated neurological disorder, cognitive abilities and oral motor function, affected children may experience anything from stigmatization and social neglect to numerous daily clothing changes, perioral dermatitis [skin irritation around the mouth], aspiration pneumonia or even dehydration."

Arthur R. T. Scheffer, M.D., of Radboud University Medical Center, Nijmegen, the Netherlands, and colleagues studied 131 children diagnosed as having cerebral palsy or other non-progressive neurological disorder, and who also had moderate to severe drooling, to test the efficacy of botulinum toxin when used as a treatment for drooling in children with neurological disorders. For the injection of the toxin, children were under general anesthesia and the injections were limited to the submandibular glands, which are responsible for 70 percent of resting saliva production. The sublingual glands and parotid glands were not treated.

Of the 131 children participating in the study, 77 were boys and 54 girls with an average age of 10.9 (age range was 3 to 27 years). About 90 percent of the patients were diagnosed as having cerebral palsy. The researchers developed a drooling quotient to assess the severity of drooling, and this measurement served as the primary measure for both efficacy and duration of botulinum toxin treatment. At the two-month follow-up, the average drooling quotient had decreased from 28.8 (on a scale of zero to 100) at the start of the study (baseline) to 15.5 and 61 patients experienced a 50 percent reduction in the drooling quotient from baseline. At the eight-month follow up, the drooling quotient increased slightly to 18.7, but the authors noted there was still a significant difference compared to baseline assessment.

Additionally, patients benefited from the botulinum toxin injection for an average of 22 weeks and 25 percent of initial responders (11.3 percent of entire population) still showed a clinically significant response to the treatment after 33 weeks, with a handful of patients experiencing continued relief from drooling after one year. "Secondary beneficial effects following injection included improved oral hygiene (reduced perioral dermatitis or reduction in halitosis) in four patients (3.1 percent) and improved speech in another four patients. These effects generally disappeared after eight months."

The authors conclude that their findings "indicate that most patients who initially respond well to injection can expect an effect to last between 19 and 33 weeks. Although the 46.6 percent success rate might appear low, its safety and efficacy make botulinum toxin a useful first-line invasive treatment if conservative measures have failed."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Arthur R. T. Scheffer; Corrie Erasmus; Karen van Hulst; Jacques van Limbeek; Peter H. Jongerius; Frank J. A. van den Hoogen. Efficacy and Duration of Botulinum Toxin Treatment for Drooling in 131 Children. Arch Otolaryngol Head Neck Surg, 2010; 136 (9): 873-877 [link]

Cite This Page:

JAMA and Archives Journals. "Botulinum toxin may offer temporary drooling relief in children with neurological disorders." ScienceDaily. ScienceDaily, 24 September 2010. <www.sciencedaily.com/releases/2010/09/100920172638.htm>.
JAMA and Archives Journals. (2010, September 24). Botulinum toxin may offer temporary drooling relief in children with neurological disorders. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2010/09/100920172638.htm
JAMA and Archives Journals. "Botulinum toxin may offer temporary drooling relief in children with neurological disorders." ScienceDaily. www.sciencedaily.com/releases/2010/09/100920172638.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins