Sep. 21, 2010 Researchers have discovered that women, female monkeys and female mice have major similarities when it comes to how bisphenol A (BPA) is metabolized, and they have renewed their call for governmental regulation when it comes to the estrogen-like chemical found in many everyday products.
A study published online in the Sept. 20 NIH journal Environmental Health Perspectives ties rodent data on the health effects of BPA to predictions of human health effects from BPA with the use of everyday household products. The study was authored by researchers at the University of Missouri Division of Biological Sciences, Veterinary Medical Diagnostic Lab (VMDL) and the department of Biomedical Sciences, in collaboration with scientists at the University of California-Davis and Washington State University.
"This study provides convincing evidence that BPA is dangerous to our health at current levels of human exposure," said Fredrick vom Saal, Curators' professor of biological sciences at the University of Missouri. "The new results clearly demonstrate that rodent data on the health effects of BPA are relevant to predictions regarding the health effects of human exposure to BPA. Further evidence of human harm should not be required for regulatory action to reduce human exposure to BPA."
BPA is one of the world's highest production-volume chemicals, with more than 8 billion pounds made per year. It can be found in a wide variety of consumer products, including hard plastic items such as baby bottles and food-storage containers, the plastic lining of food and beverage cans, thermal paper used for receipts, and dental sealants. The findings in the current study suggest that human exposure to BPA is much higher than some prior estimates and is likely to be from many still-unknown sources, indicating the need for governmental agencies to require the chemical industry to identify all products that contain BPA.
Several states, including Connecticut, Massachusetts, Washington, New York and Oregon, have passed bills to reduce exposure to BPA, and similar legislation is pending in the U.S. Congress.
"For years, BPA manufacturers have argued that BPA is safe and have denied the validity of more than 200 studies that showed adverse health effects in animals due to exposure to very low doses of BPA," said Julia Taylor, lead author and associate research professor at the University of Missouri. "We know that BPA leaches out of products that contain it, and that it acts like estrogen in the body."
"We've assumed we're getting BPA from the ingestion of contaminated food and beverages," said co-author Pat Hunt, a professor in the Washington State University School of Molecular Biosciences. "This indicates there must be a lot of other ways in which we're exposed to this chemical and we're probably exposed to much higher levels than we have assumed."
The research team at the University of Missouri includes Taylor, vom Saal and student researcher Bertram Drury in Biological Sciences, as well as Wade Welshons in Biomedical Sciences and George Rottinghaus in the VMDL at MU.
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- Julia A. Taylor, Frederick S. vom Saal, Wade V. Welshons, Bertram Drury, George Rottinghaus, Patricia A. Hunt, Catherine A. VandeVoort. Similarity of Bisphenol A Pharmacokinetics in Rhesus Monkeys and Mice: Relevance for Human Exposure. Environmental Health Perspectives, 2010; DOI: 10.1289/ehp.1002514
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