Featured Research

from universities, journals, and other organizations

First explanation of how cells rapidly repair and maintain structure

Date:
September 22, 2010
Source:
University of Utah Health Sciences
Summary:
Researchers have discovered that a protein, zyxin, is necessary for the maintenance and repair of the cell's cytoskeleton, or internal framework, which serves as the muscle and bone of the cell.

Researchers at Huntsman Cancer Institute (HCI) at the University of Utah have discovered that a protein, zyxin, is necessary for the maintenance and repair of the cell's cytoskeleton, or internal framework, which serves as the muscle and bone of the cell. The research has implications for cancer, as well as other diseases, since alterations in the cytoskeleton are often associated with disease. The research was published in the Sep. 14, 2010, issue of the journal Developmental Cell.

Related Articles


"Just like people, the cells in our bodies are exposed to all kinds of stress," says Mary Beckerle, Ph.D., the study's principal investigator and HCI executive director. "One type of stress, mechanical stress that is derived from application of physical force, is experienced by many organs such as the lung, which stretches with each breath, the heart, which is physically challenged with each beat, and the uterus, which undergoes intense contractions during labor and childbirth. We were interested in how living cells respond to such stress. In this study, we showed that mechanical stress can damage the cytoskeleton but that cells have special machinery that rapidly recognizes the damage and repairs it."

Mark Smith, Ph.D., one of the HCI researchers involved in the study explains that, "When a cell's environment changes and stress is applied, cytoskeletal bundles, called actin stress fibers, can literally begin to tear, but then are rapidly repaired. This process begins within seconds and allows the cell to retain its structure. We showed that a protein called zyxin is required for the maintenance and repair of the actin cytoskeleton." Zyxin expression is down-regulated in certain cancers and future experiments will explore whether loss of this cytoskeletal repair pathway in tumor cells is responsible for the disruption of the cytoskeleton that is common in cancer cells.

The researchers studied the process by imaging live cells that expressed fluorescently tagged cytoskeletal proteins. This allowed them to observe the mechanism whereby actin stress fibers maintain homeostasis, or balance. The repair mechanism was directly triggered by force and served to relieve mechanical stress on actin stress fibers, which in turn provided a system for rapid response to force changes in the extracellular environment.

The study was funded by the National Institute of General Medical Sciences. Other HCI researchers involved in the study include Elizabeth Blankman and Laura Luettjohann. Margaret L. Gardel from the University of Chicago, and Clare M. Waterman, from the National Heart, Lung and Blood Institute, also contributed to the work.


Story Source:

The above story is based on materials provided by University of Utah Health Sciences. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mark A. Smith, Elizabeth Blankman, Margaret L. Gardel, Laura Luettjohann, Clare M. Waterman, Mary C. Beckerle. A Zyxin-Mediated Mechanism for Actin Stress Fiber Maintenance and Repair. Developmental Cell, 2010; 19 (3): 365 DOI: 10.1016/j.devcel.2010.08.008

Cite This Page:

University of Utah Health Sciences. "First explanation of how cells rapidly repair and maintain structure." ScienceDaily. ScienceDaily, 22 September 2010. <www.sciencedaily.com/releases/2010/09/100921171414.htm>.
University of Utah Health Sciences. (2010, September 22). First explanation of how cells rapidly repair and maintain structure. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2010/09/100921171414.htm
University of Utah Health Sciences. "First explanation of how cells rapidly repair and maintain structure." ScienceDaily. www.sciencedaily.com/releases/2010/09/100921171414.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins