Featured Research

from universities, journals, and other organizations

Microbiologists find source of fungus’s damaging growth

Date:
September 24, 2010
Source:
University of Texas Health Science Center at San Antonio
Summary:
Candida albicans, a fungus that kills more than 10,000 people with weakened immune systems each year, grows more dangerous as it forms and extends long strands of cells called hyphal filaments. In a new study, microbiologists describe a key factor involved in this damaging growth.

This is an image of hyphal Candida albicans cells. This fungus attacks patients with weakened immune systems. It also causes yeast infections and oral thrush.
Credit: David Kadosh, Ph.D., UT Health Science Center San Antonio

Candida albicans, a fungus that kills more than 10,000 people with weakened immune systems each year, grows more dangerous as it forms and extends long strands of cells called hyphal filaments. In a paper published this month, UT Health Science Center San Antonio microbiologists describe a key factor involved in this damaging growth.

Related Articles


This finding may eventually lead to targets for antifungal strategies, the scientists said.

Patricia Carlisle, a Ph.D. student at the Health Science Center, and David Kadosh, Ph.D., assistant professor of microbiology, found that Ume6, a key transcriptional regulator, targets a specific hyphal filament-development mechanism. "No one knew that Ume6 was involved in directing this process," Dr. Kadosh said. "Perhaps we can learn how to mute its signals."

Transcriptional regulators direct the conversion of DNA (deoxyribonucleic acid) into RNA copies. Copies of RNA (ribonucleic acid) are translated into proteins that carry out activity.

Bug's impact

Candida albicans preys on hospitalized critical care patients, HIV/AIDS patients, cancer patients and others with weakened immune systems. It is the fourth-leading cause of hospital-acquired infections in the United States.

"The forming of hyphal filaments is very important in tissue invasion and other activities," Dr. Kadosh said.

The findings were featured as a Spotlight article in the September issue of Eukaryotic Cell, a journal of the American Society for Microbiology.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at San Antonio. Note: Materials may be edited for content and length.


Journal Reference:

  1. P. L. Carlisle, D. Kadosh. Candida albicans Ume6, a Filament-Specific Transcriptional Regulator, Directs Hyphal Growth via a Pathway Involving Hgc1 Cyclin-Related Protein. Eukaryotic Cell, 2010; 9 (9): 1320 DOI: 10.1128/EC.00046-10

Cite This Page:

University of Texas Health Science Center at San Antonio. "Microbiologists find source of fungus’s damaging growth." ScienceDaily. ScienceDaily, 24 September 2010. <www.sciencedaily.com/releases/2010/09/100922171610.htm>.
University of Texas Health Science Center at San Antonio. (2010, September 24). Microbiologists find source of fungus’s damaging growth. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2010/09/100922171610.htm
University of Texas Health Science Center at San Antonio. "Microbiologists find source of fungus’s damaging growth." ScienceDaily. www.sciencedaily.com/releases/2010/09/100922171610.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins