Featured Research

from universities, journals, and other organizations

New level of control for the heart beat

Date:
September 28, 2010
Source:
Journal of Clinical Investigation
Summary:
The heart beat, nerve cell communication, and skeletal muscle function are all controlled by channels in the cell membrane that regulate the movement of sodium ions (Na+). Mutations in these so called voltage-gated Na+ channels result in forms of epilepsy and heart conditions such as long QT syndrome that are characterized by an irregular heart beat.

The heart beat, nerve cell communication, and skeletal muscle function are all controlled by channels in the cell membrane that regulate the movement of sodium ions (Na+). Mutations in these so called voltage-gated Na+ channels result in forms of epilepsy and heart conditions such as long QT syndrome that are characterized by an irregular heart beat.

New research, conducted by a team of investigators led by Peter Mohler and Thomas Hund, at the University of Iowa Carver College of Medicine, Iowa City, has now identified a multifunctional regulatory platform for voltage-gated Na+ channels in mice.

In the study, the structural protein beta-IV-spectrin was found to be part of the multi-protein complex containing the predominant voltage-gated Na+ channel in heart muscle cells in mice. Further, beta-IV-spectrin recruited to the multi-protein complex the protein CaMKII, which in turn modified the voltage-gated Na+ channel, modulating its function. In the presence of mutant forms of beta-IV-spectrin, the function of the voltage-gated Na+ channel in the heart was impaired and the mice exhibited an abnormal heart beat. As discussed by Robert Kass and Kevin Sampson, at Columbia University, New York, in an accompanying commentary, these data provide new insight into the control of the heart beat and might provide new therapeutic targets.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Thomas J. Hund, Olha M. Koval, Jingdong Li, Patrick J. Wright, Lan Qian, Jedidiah S. Snyder, Hjalti Gudmundsson, Crystal F. Kline, Nathan P. Davidson, Natalia Cardona, Matthew N. Rasband, Mark E. Anderson, Peter J. Mohler. A βIV-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI43621

Cite This Page:

Journal of Clinical Investigation. "New level of control for the heart beat." ScienceDaily. ScienceDaily, 28 September 2010. <www.sciencedaily.com/releases/2010/09/100927122217.htm>.
Journal of Clinical Investigation. (2010, September 28). New level of control for the heart beat. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/2010/09/100927122217.htm
Journal of Clinical Investigation. "New level of control for the heart beat." ScienceDaily. www.sciencedaily.com/releases/2010/09/100927122217.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins