Featured Research

from universities, journals, and other organizations

New level of control for the heart beat

Date:
September 28, 2010
Source:
Journal of Clinical Investigation
Summary:
The heart beat, nerve cell communication, and skeletal muscle function are all controlled by channels in the cell membrane that regulate the movement of sodium ions (Na+). Mutations in these so called voltage-gated Na+ channels result in forms of epilepsy and heart conditions such as long QT syndrome that are characterized by an irregular heart beat.

The heart beat, nerve cell communication, and skeletal muscle function are all controlled by channels in the cell membrane that regulate the movement of sodium ions (Na+). Mutations in these so called voltage-gated Na+ channels result in forms of epilepsy and heart conditions such as long QT syndrome that are characterized by an irregular heart beat.

Related Articles


New research, conducted by a team of investigators led by Peter Mohler and Thomas Hund, at the University of Iowa Carver College of Medicine, Iowa City, has now identified a multifunctional regulatory platform for voltage-gated Na+ channels in mice.

In the study, the structural protein beta-IV-spectrin was found to be part of the multi-protein complex containing the predominant voltage-gated Na+ channel in heart muscle cells in mice. Further, beta-IV-spectrin recruited to the multi-protein complex the protein CaMKII, which in turn modified the voltage-gated Na+ channel, modulating its function. In the presence of mutant forms of beta-IV-spectrin, the function of the voltage-gated Na+ channel in the heart was impaired and the mice exhibited an abnormal heart beat. As discussed by Robert Kass and Kevin Sampson, at Columbia University, New York, in an accompanying commentary, these data provide new insight into the control of the heart beat and might provide new therapeutic targets.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Thomas J. Hund, Olha M. Koval, Jingdong Li, Patrick J. Wright, Lan Qian, Jedidiah S. Snyder, Hjalti Gudmundsson, Crystal F. Kline, Nathan P. Davidson, Natalia Cardona, Matthew N. Rasband, Mark E. Anderson, Peter J. Mohler. A βIV-spectrin/CaMKII signaling complex is essential for membrane excitability in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI43621

Cite This Page:

Journal of Clinical Investigation. "New level of control for the heart beat." ScienceDaily. ScienceDaily, 28 September 2010. <www.sciencedaily.com/releases/2010/09/100927122217.htm>.
Journal of Clinical Investigation. (2010, September 28). New level of control for the heart beat. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2010/09/100927122217.htm
Journal of Clinical Investigation. "New level of control for the heart beat." ScienceDaily. www.sciencedaily.com/releases/2010/09/100927122217.htm (accessed January 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, January 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins