Featured Research

from universities, journals, and other organizations

New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer

Date:
October 9, 2010
Source:
European Society for Medical Oncology
Summary:
A subset of lung cancer patients seem to live longer and experience delays in disease progression when a new drug that targets a cancer-associated molecule called MET is added to treatment with erlotinib, the results of a double-blind Phase II trial show.

A subset of lung cancer patients seem to live longer and experience delays in disease progression when a new drug that targets a cancer-associated molecule called MET is added to treatment with erlotinib, the results of a double-blind Phase-II trial show.

Related Articles


Dr David Spigel, Director of lung cancer research for the Sarah Cannon Research Institute in Nashville, Tennessee reported the trial findings at the 35th Congress of the European Society for Medical Oncology (ESMO) in Milan, Italy.

The study included 128 patients with advanced non-small cell lung cancer who were randomly assigned to treatment with either erlotinib plus placebo, or erlotinib plus MetMAb, a monoclonal antibody that binds specifically to the MET receptor on cancer cells.

"MET is an important switch in cancer cells," Dr Spigel explained. "When turned on, it influences the growth of these cells. Importantly, MET activation has also been implicated in the resistance of lung cancers to EGFR inhibitors such as erlotinib. MetMAb helps target this switch and turn it off."

Dr Spigel and colleagues tested for mutations in the EGFR gene and for expression of MET in tumor samples from trial participants.

At the end of the trial, the researchers found that among the 51% of patients whose tumors expressed MET, those who received MetMAb plus erlotinib had better overall survival and longer progression-free survival than those who received erlotinib plus placebo.

In this subset of Met+ patients, adding MetMAb to erlotinib nearly halved the risk of disease progression or death during the study compared to those treated with erlotinib plus placebo.

"In those patients who were found to express the MET protein (the target of MetMAb), MetMAb appeared to improve the treatment benefit when added to erlotinib compared with erlotinib alone," Dr Spigel said.

Conversely, patients whose tumors did not express the MET protein appeared to do worse when treated with the MetMAb/erlotinib combination. "The reasons for this finding are unclear. It is possible that MetMAb may interfere with erlotinib's activity in these patients, but further study would be necessary to better understand this potential negative association," Dr Spigel said.

"The findings of this trial are important, and need to be validated in a larger randomized Phase-III trial in patients selected for MET expression," Dr Spigel said.

The results of this trial are important for three reasons, commented Professor Jean-Charles Soria from Institut Gustave Roussy, Paris, France.

"First, this is the second trial in lung cancer where targeting of MET in combination with erlotinib suggests a better outcome," Prof Soria said. "This confirms that MET is a relevant target in cancer."

"Also, the present Genentech-sponsored trial has identified a putative biomarker, namely MET immunohistochemical positivity, which appears to be easy to implement as immunohistochemistry testing is daily practice in pathology labs."

"Finally, in the present trial the biomarker-positive population not only derived a benefit in progression-free survival, but also an almost statistical overall survival benefit, which is remarkable taking into account the small number of patients. One note of caution, however, is that these Phase-II results should be validated in a larger Phase-III trial."


Story Source:

The above story is based on materials provided by European Society for Medical Oncology. Note: Materials may be edited for content and length.


Cite This Page:

European Society for Medical Oncology. "New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer." ScienceDaily. ScienceDaily, 9 October 2010. <www.sciencedaily.com/releases/2010/10/101009082816.htm>.
European Society for Medical Oncology. (2010, October 9). New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2010/10/101009082816.htm
European Society for Medical Oncology. "New targeted therapy adds benefit to erlotinib in some patients with advanced lung cancer." ScienceDaily. www.sciencedaily.com/releases/2010/10/101009082816.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com
Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins