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New treatment may protect against pneumonia

Date:
October 17, 2010
Source:
American Society for Microbiology
Summary:
Intranasal administration of the protein flagellin may activate innate immunity and protect against acute pneumonia, say researchers from France.

Intranasal administration of the protein flagellin may activate innate immunity and protect against acute pneumonia say researchers from France.

They report their findings in the October 2010 issue of the journal Infection and Immunity.

Streptococcus pneumoniae is a major cause of respiratory infections in infants and the elderly worldwide. Many humans carry the bacterium in their throat, but remain asymptomatic due to activated innate immunity, however, inadequate immune responses in susceptible individuals can result in invasive pneumococcal pneumonia.

Researchers determined the capacity of flagellin to protect against pneumonia by intranasally inoculating two groups of mice with S. pneumoniae and simultaneously treating only one with flagellin. Mice treated with flagellin had a survival rate between 75 and 100% while untreated mice died within 3 to 4 days. Also, infected mice receiving flagellin treatment demonstrated significant bacterial reduction in the lungs after 24 hours and complete clearance after 2 days.

Additionally, researchers evaluated the therapeutic value of flagellin treatment by infecting two groups of mice with S. pneumoniae and then intranasally administering flagellin to only one after 24 hours. Protection levels among treated mice were 60 to 100 %, while all untreated mice died.

"Our results showed that local stimulation with a single and well-characterized molecule, specifically flagellin, is sufficient for augmenting lung innate immune defenses and controlling pneumococcal pneumonia, highlighting the benefits of using microbe-associated molecular patterns as the basis for developing antimicrobial therapies," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. N. Munoz, L. Van Maele, J. M. Marques, A. Rial, J.-C. Sirard, J. A. Chabalgoity. Mucosal Administration of Flagellin Protects Mice from Streptococcus pneumoniae Lung Infection. Infection and Immunity, 2010; 78 (10): 4226 DOI: 10.1128/IAI.00224-10

Cite This Page:

American Society for Microbiology. "New treatment may protect against pneumonia." ScienceDaily. ScienceDaily, 17 October 2010. <www.sciencedaily.com/releases/2010/10/101016080122.htm>.
American Society for Microbiology. (2010, October 17). New treatment may protect against pneumonia. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2010/10/101016080122.htm
American Society for Microbiology. "New treatment may protect against pneumonia." ScienceDaily. www.sciencedaily.com/releases/2010/10/101016080122.htm (accessed October 2, 2014).

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