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Western diet exacerbates sepsis, mouse study suggests

Date:
October 19, 2010
Source:
BioMed Central
Summary:
High-fat diets cause a dramatic immune system overreaction to sepsis, a condition of systemic bacterial infection. An experimental study in mice has shown that a diet high in saturated fat, sugars and cholesterol greatly exaggerates the inflammatory response to sepsis.

High fat diets cause a dramatic immune system overreaction to sepsis, a condition of systemic bacterial infection. An experimental study in mice, published in the open access journal BMC Physiology, has shown that a diet high in saturated fat, sugars and cholesterol greatly exaggerates the inflammatory response to sepsis.

Chantal Rivera, PhD Associate Professor of Molecular and Cellular Physiology at Louisiana State University Health Sciences Center-Shreveport, said that "Mortality due to sepsis in morbidly obese subjects is estimated to be 7 times more prevalent compared to mortality in lean individuals. Morbidity in obese patients is also more severe. Results from our recent studies suggest that this adverse outcome may be caused by consuming a high-fat diet, which predisposes the immune system to react more strongly to infection."

Dr. Rivera lead a team of researchers to carry out the surgical induction of sepsis in mice that had been fed normal chow or western diet for 3 weeks. Mice on the western diet, which was enriched in saturated fat, showed exacerbated inflammation that was found to be mediated by signaling via the toll-like receptor 4 (TLR-4) pathway.

According to Dr Rivera, "These results suggest that targeting the TLR signaling pathway as a therapeutic approach to the medical management of sepsis may be especially beneficial in obese patients."


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chantal A Rivera, LaTausha Gaskin, Georg Singer, Jeff Houghton and Monique Allman. Western diet enhances hepatic inflammation in mice exposed to cecal ligation and puncture. BMC Physiology, (in press) [link]

Cite This Page:

BioMed Central. "Western diet exacerbates sepsis, mouse study suggests." ScienceDaily. ScienceDaily, 19 October 2010. <www.sciencedaily.com/releases/2010/10/101018211818.htm>.
BioMed Central. (2010, October 19). Western diet exacerbates sepsis, mouse study suggests. ScienceDaily. Retrieved August 29, 2014 from www.sciencedaily.com/releases/2010/10/101018211818.htm
BioMed Central. "Western diet exacerbates sepsis, mouse study suggests." ScienceDaily. www.sciencedaily.com/releases/2010/10/101018211818.htm (accessed August 29, 2014).

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