Featured Research

from universities, journals, and other organizations

Progress toward treating infections by silencing microbes' 'smart phones'

Date:
October 20, 2010
Source:
American Chemical Society
Summary:
So disease-causing bacteria in the body finally have multiplied to the point where their numbers are large enough to cause illness. What's next? They get out their "smart phones" and whisper "Let's roll!" That's how a new review describes the substances -- "smart phones of the microbial world" -- that bacteria use to transmit chemical signals that launch infections and monitor their environment. The authors describe progress toward understanding and blocking this biochemical chitchat.

So disease-causing bacteria in the body finally have multiplied to the point where their numbers are large enough to cause illness. What's next? They get out their "smart phones" and whisper "Let's roll!"

Related Articles


That's how an article in ACS' monthly Chemical Reviews describes the substances -- "smart phones of the microbial world" -- that bacteria use to transmit chemical signals that launch infections and monitor their environment. The authors describe progress toward understanding and blocking this biochemical chitchat, a development that could lead to new treatments for the growing problem of antibiotic-resistant infections.

Marvin Whiteley and Holly Huse point out that bacteria use chemical signals to communicate with each other. These signals can trigger infections when their numbers reach a certain threshold -- a process known as "quorum sensing." Scientists around the world are trying to find potential new drugs that garble or block those signals, and in doing so, fight infection. One prime target are the 4-quinolones, signaling molecules produced by Pseudomonas aeruginosa, a common disease-causing microbe.

Their review of more than 60 years of research on 4-quinolones found promising indications that such a conversation-stopper will be developed. Scientists, for instance, now have evidence that a certain enzyme that modifies 4-quinolones can reduce infection. "These results are encouraging for the development of new therapeutics that target 4-quinolone signaling," the article noted.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Holly Huse, Marvin Whiteley. 4-Quinolones: Smart Phones of the Microbial World. Chemical Reviews, 2010; 100811103829046 DOI: 10.1021/cr100063u

Cite This Page:

American Chemical Society. "Progress toward treating infections by silencing microbes' 'smart phones'." ScienceDaily. ScienceDaily, 20 October 2010. <www.sciencedaily.com/releases/2010/10/101020121214.htm>.
American Chemical Society. (2010, October 20). Progress toward treating infections by silencing microbes' 'smart phones'. ScienceDaily. Retrieved December 20, 2014 from www.sciencedaily.com/releases/2010/10/101020121214.htm
American Chemical Society. "Progress toward treating infections by silencing microbes' 'smart phones'." ScienceDaily. www.sciencedaily.com/releases/2010/10/101020121214.htm (accessed December 20, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, December 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Monarch Butterflies Descend Upon Mexican Forest During Annual Migration

Reuters - Light News Video Online (Dec. 19, 2014) Millions of monarch butterflies begin to descend onto Mexico as part of their annual migration south. Rough Cut (no reporter narration) Video provided by Reuters
Powered by NewsLook.com
The Best Protein-Filled Foods to Energize You for the New Year

The Best Protein-Filled Foods to Energize You for the New Year

Buzz60 (Dec. 19, 2014) The new year is coming and nothing will energize you more for 2015 than protein-filled foods. Fitness and nutrition expert John Basedow (@JohnBasedow) gives his favorite high protein foods that will help you build muscle, lose fat and have endless energy. Video provided by Buzz60
Powered by NewsLook.com
Birds Might Be Better Meteorologists Than Us

Birds Might Be Better Meteorologists Than Us

Newsy (Dec. 19, 2014) A new study suggests a certain type of bird was able to sense a tornado outbreak that moved through the U.S. a day before it hit. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins