Featured Research

from universities, journals, and other organizations

Progress toward treating infections by silencing microbes' 'smart phones'

Date:
October 20, 2010
Source:
American Chemical Society
Summary:
So disease-causing bacteria in the body finally have multiplied to the point where their numbers are large enough to cause illness. What's next? They get out their "smart phones" and whisper "Let's roll!" That's how a new review describes the substances -- "smart phones of the microbial world" -- that bacteria use to transmit chemical signals that launch infections and monitor their environment. The authors describe progress toward understanding and blocking this biochemical chitchat.

So disease-causing bacteria in the body finally have multiplied to the point where their numbers are large enough to cause illness. What's next? They get out their "smart phones" and whisper "Let's roll!"

Related Articles


That's how an article in ACS' monthly Chemical Reviews describes the substances -- "smart phones of the microbial world" -- that bacteria use to transmit chemical signals that launch infections and monitor their environment. The authors describe progress toward understanding and blocking this biochemical chitchat, a development that could lead to new treatments for the growing problem of antibiotic-resistant infections.

Marvin Whiteley and Holly Huse point out that bacteria use chemical signals to communicate with each other. These signals can trigger infections when their numbers reach a certain threshold -- a process known as "quorum sensing." Scientists around the world are trying to find potential new drugs that garble or block those signals, and in doing so, fight infection. One prime target are the 4-quinolones, signaling molecules produced by Pseudomonas aeruginosa, a common disease-causing microbe.

Their review of more than 60 years of research on 4-quinolones found promising indications that such a conversation-stopper will be developed. Scientists, for instance, now have evidence that a certain enzyme that modifies 4-quinolones can reduce infection. "These results are encouraging for the development of new therapeutics that target 4-quinolone signaling," the article noted.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Holly Huse, Marvin Whiteley. 4-Quinolones: Smart Phones of the Microbial World. Chemical Reviews, 2010; 100811103829046 DOI: 10.1021/cr100063u

Cite This Page:

American Chemical Society. "Progress toward treating infections by silencing microbes' 'smart phones'." ScienceDaily. ScienceDaily, 20 October 2010. <www.sciencedaily.com/releases/2010/10/101020121214.htm>.
American Chemical Society. (2010, October 20). Progress toward treating infections by silencing microbes' 'smart phones'. ScienceDaily. Retrieved March 26, 2015 from www.sciencedaily.com/releases/2010/10/101020121214.htm
American Chemical Society. "Progress toward treating infections by silencing microbes' 'smart phones'." ScienceDaily. www.sciencedaily.com/releases/2010/10/101020121214.htm (accessed March 26, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, March 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Jockey Motion Tracking Reveals Racing Prowess

Jockey Motion Tracking Reveals Racing Prowess

Reuters - Innovations Video Online (Mar. 26, 2015) Using motion tracking technology, researchers from the Royal Veterinary College (RVC) are trying to establish an optimum horse riding style to train junior jockeys, as well as enhance safety, health and well-being of both racehorses and jockeys. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Botswana Talks to End Illegal Wildlife Trade

Botswana Talks to End Illegal Wildlife Trade

AFP (Mar. 25, 2015) Experts are gathering in Botswana to try to end the illegal wildlife trade that is decimating populations of elephants, rhinos and other threatened species. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Elephants Help Keep 18-Wheeler From Toppling Over

Elephants Help Keep 18-Wheeler From Toppling Over

Newsy (Mar. 25, 2015) The Natchitoches Parish Sheriff&apos;s Office discovered two elephants keeping a tractor-trailer that had gotten stuck in some mud upright on a highway. Video provided by Newsy
Powered by NewsLook.com
Baby 'pet' Orangutan Rescued from Chicken Cage Takes First Steps

Baby 'pet' Orangutan Rescued from Chicken Cage Takes First Steps

Reuters - Light News Video Online (Mar. 25, 2015) Buti, a baby orangutan who was left malnourished in a chicken cage before his rescue, takes his first steps after months of painful physical therapy. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins