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Promising new 'antigene' therapy uses light energy to silence gene activity

Date:
October 21, 2010
Source:
Mary Ann Liebert, Inc./Genetic Engineering News
Summary:
Antigene therapy is a promising new treatment strategy that uses a DNA-based drug to pinpoint light energy to a target gene shutting down its activity.

Antigene therapy is a promising new treatment strategy that uses a DNA-based drug to pinpoint light energy to a target gene shutting down its activity. A review article published in Oligonucleotides details the possibilities and challenges for the clinical application of this novel photo-activated DNA modulating approach.

Netanel Kolevzon and Eylon Yavin, from The Hebrew University of Jerusalem (Israel), describe the mechanism behind antigene therapy in the article. They review the development of triplex-forming DNA-based drugs capable of up-regulating or inhibiting gene expression in a highly targeted and selective manner.

Unlike existing antisense therapies that target RNA, an antigene drug is a triplex-forming oligonucleotide that recognizes and attaches directly to a specific DNA sequence. By attaching a photoreactive agent to the antigene and delivering light energy to the attachment site, the light-sensitive drug complex becomes activated, triggering a cleavage or cross-linking reaction. This photo-induced, site-specific DNA damage effectively silences the gene target.

"Many obstacles lay ahead before this approach may reach the clinic," caution the authors. However, if antigene therapy proves successful at blocking gene activity, "many diseases that are currently incurable or otherwise treatable with limited success could be potentially relevant targets for such an approach," they conclude.

"This is a clever and potentially powerful approach to targeted regulation of gene expression," says John Rossi, PhD, Co-Editor-in-Chief of Oligonucleotides and Professor in the Department of Molecular Biology, Beckman Research Institute of the City of Hope (Duarte, CA).


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc./Genetic Engineering News. Note: Materials may be edited for content and length.


Journal Reference:

  1. Netanel Kolevzon, Eylon Yavin. Site-Specific DNA Photocleavage and Photomodulation by Oligonucleotide Conjugates. Oligonucleotides, 2010; 101020122647013 DOI: 10.1089/oli.2010.0247

Cite This Page:

Mary Ann Liebert, Inc./Genetic Engineering News. "Promising new 'antigene' therapy uses light energy to silence gene activity." ScienceDaily. ScienceDaily, 21 October 2010. <www.sciencedaily.com/releases/2010/10/101021124924.htm>.
Mary Ann Liebert, Inc./Genetic Engineering News. (2010, October 21). Promising new 'antigene' therapy uses light energy to silence gene activity. ScienceDaily. Retrieved September 1, 2014 from www.sciencedaily.com/releases/2010/10/101021124924.htm
Mary Ann Liebert, Inc./Genetic Engineering News. "Promising new 'antigene' therapy uses light energy to silence gene activity." ScienceDaily. www.sciencedaily.com/releases/2010/10/101021124924.htm (accessed September 1, 2014).

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