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'At-TRIB(1)-uting' a gene a new function in the liver

Date:
November 15, 2010
Source:
Journal of Clinical Investigation
Summary:
Specific, relatively uncommon variations at a region of human chromosome 8 have recently been linked to fat (lipid) levels in the blood that decrease an individual's risk of atherosclerosis. The only currently described gene in this region of chromosome 8 is TRIB1, but it had not been previously linked to regulation of lipid levels. Now, however, researchers have identified in mice a role for this gene in regulating lipid production by the liver.
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Specific, relatively uncommon variations at a region of human chromosome 8 have recently been linked to fat (lipid) levels in the blood that decrease an individual's risk of atherosclerosis (a disease of the major arterial blood vessels that is a main cause of heart attack and stroke).

The only currently described gene in this region of chromosome 8 is TRIB1, but it has not been previously linked in any way to regulation of lipid levels.

Now, a team of researchers, led by Jan Breslow, at The Rockefeller University, New York, and Daniel Rader, at the University of Pennsylvania School of Medicine, Philadelphia, has identified in mice a role for this gene in regulating lipid production by the liver. Specifically, overexpression of Trib1 in the liver decreased levels of lipids such as cholesterol in the blood, while lack of Trib1 increased levels of the same lipids.

These data suggest that TRIB1 is the gene responsible for the associations between chromosome 8 and lipid levels in the blood.


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The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ralph Burkhardt et al. Trib1 is a lipid- and myocardial infarction–associated gene that regulates hepatic lipogenesis and VLDL production in mice. Journal of Clinical Investigatin, November 15, 2010 DOI: 10.1172/JCI44213

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Journal of Clinical Investigation. "'At-TRIB(1)-uting' a gene a new function in the liver." ScienceDaily. ScienceDaily, 15 November 2010. <www.sciencedaily.com/releases/2010/11/101115122637.htm>.
Journal of Clinical Investigation. (2010, November 15). 'At-TRIB(1)-uting' a gene a new function in the liver. ScienceDaily. Retrieved May 24, 2015 from www.sciencedaily.com/releases/2010/11/101115122637.htm
Journal of Clinical Investigation. "'At-TRIB(1)-uting' a gene a new function in the liver." ScienceDaily. www.sciencedaily.com/releases/2010/11/101115122637.htm (accessed May 24, 2015).

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