Featured Research

from universities, journals, and other organizations

Fatal blood clot genetic risk identified

Date:
November 28, 2010
Source:
University of Leicester
Summary:
Researchers can now better identifying people at risk of developing potentially fatal blood clots that can lead to heart attack.

An international team led by researchers from the Universities of Leicester and Cambridge has announced a breakthrough in identifying people at risk of developing potentially fatal blood clots that can lead to heart attack.

Related Articles


The discovery, published the week of November 25 in the haematology journal Blood, is expected to advance ways of detecting and treating coronary heart disease -- the most common form of disease affecting the heart and an important cause of premature death.

The research led by Professor Alison Goodall from the University of Leicester and Professor Willem Ouwehand from the University of Cambridge and NHS Blood and Transplant was carried out in collaboration with colleagues at the Wellcome Trust Sanger Institute, University College Dublin, and the University of Leuven, as part of a large programme to discover novel genes regulating platelets; the tiny cells in the blood that stick together to form a blood clot.

Understanding what makes these cells more sticky in some people than others could provide potential therapeutic targets for treatment of cardiovascular disease.

Lead author Professor Goodall, of the Department of Cardiovascular Sciences at the University of Leicester, said: "We have long known that platelet activity and clot formation varied between different people -- but we now have identified some of the genetic reasons for this."

Professor Ouwehand said the research had uncovered a new molecule that plays an important role in platelets. He said: "Studies in large number of NHS patients who experienced a heart attack and healthy controls suggests that genetic differences in the gene for this protein slightly modifies the risk for blood clots. This type of study will help us to unravel the complex question why some people have a higher risk of a heart attack than others. One day this type of research may lead to a new generation of drugs that can be used to reduce the risk of this devastating disease."

The study was carried out as part of the European Union funded Bloodomics's project.


Story Source:

The above story is based on materials provided by University of Leicester. Note: Materials may be edited for content and length.


Journal Reference:

  1. A. H. Goodall, P. Burns, I. Salles, I. C. Macaulay, C. I. Jones, D. Ardissino, B. de Bono, S. L. Bray, H. Deckmyn, F. Dudbridge, D. J. Fitzgerald, S. F. Garner, A. Gusnanto, K. Koch, C. Langford, M. N. O'Connor, C. M. Rice, D. Stemple, J. Stephens, M. D. Trip, J.-J. Zwaginga, N. J. Samani, N. A. Watkins, P. B. Maguire, W. H. Ouwehand. Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function. Blood, 2010; DOI: 10.1182/blood-2010-04-280925

Cite This Page:

University of Leicester. "Fatal blood clot genetic risk identified." ScienceDaily. ScienceDaily, 28 November 2010. <www.sciencedaily.com/releases/2010/11/101124214720.htm>.
University of Leicester. (2010, November 28). Fatal blood clot genetic risk identified. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2010/11/101124214720.htm
University of Leicester. "Fatal blood clot genetic risk identified." ScienceDaily. www.sciencedaily.com/releases/2010/11/101124214720.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins