Featured Research

from universities, journals, and other organizations

Massive endocytosis in cells

Date:
January 17, 2011
Source:
Rockefeller University Press
Summary:
Researchers have extensively characterized a previously unidentified process by which up to 75 percent of the cell plasma membrane can be reversibly endocytosed.

In three papers in the January and February issues of the Journal of General Physiology (JGP), Don Hilgemann and colleagues have extensively characterized a previously unidentified process by which up to 75% of the cell plasma membrane can be reversibly endocytosed.

Related Articles


This massive endocytosis ("MEND") can be elicited in a variety of cell types with a range of different experimental manipulations, including internal calcium transients in the presence of ATP, membrane treatment with sphingomyelinase, and introduction of various amphiphiles into the membrane bilayer.

MEND does not employ the canonical endocytic mechanisms involving clathrin, the actin cytoskeleton or dynamins. MEND preferentially causes endocytosis of the low-ordered, cholesterol-containing membrane fraction. The mechanisms underlying MEND likely include the merger of nanoscopic low-ordered domains into larger domains with attendant changes in lipid line tension.

Application of MEND promises to serve as a valuable tool in determining which membrane proteins are associated with low- or high-ordered membrane fractions.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal References:

  1. M. Fine, M. C. Llaguno, V. Lariccia, M.-J. Lin, A. Yaradanakul, D. W. Hilgemann. Massive endocytosis driven by lipidic forces originating in the outer plasmalemmal monolayer: a new approach to membrane recycling and lipid domains. The Journal of General Physiology, 2011; DOI: 10.1085/jgp.201010469
  2. D. W. Hilgemann, M. Fine. Mechanistic analysis of massive endocytosis in relation to functionally defined surface membrane domains. The Journal of General Physiology, 2011; DOI: 10.1085/jgp.201010470
  3. V. Lariccia, M. Fine, S. Magi, M.-J. Lin, A. Yaradanakul, M. C. Llaguno, D. W. Hilgemann. Massive calcium-activated endocytosis without involvement of classical endocytic proteins. The Journal of General Physiology, 2010; 137 (1): 111 DOI: 10.1085/jgp.201010468

Cite This Page:

Rockefeller University Press. "Massive endocytosis in cells." ScienceDaily. ScienceDaily, 17 January 2011. <www.sciencedaily.com/releases/2011/01/110117143206.htm>.
Rockefeller University Press. (2011, January 17). Massive endocytosis in cells. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2011/01/110117143206.htm
Rockefeller University Press. "Massive endocytosis in cells." ScienceDaily. www.sciencedaily.com/releases/2011/01/110117143206.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Anglerfish Rarely Seen In Its Habitat Will Haunt You

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Newsy (Nov. 22, 2014) For the first time Monterey Bay Aquarium recorded a video of the elusive, creepy and rarely seen anglerfish. Video provided by Newsy
Powered by NewsLook.com
Birds Around the World Take Flight

Birds Around the World Take Flight

Reuters - Light News Video Online (Nov. 22, 2014) An imperial eagle equipped with a camera spreads its wings over London. It's just one of the many birds making headlines in this week's "animal roundup". Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins