Featured Research

from universities, journals, and other organizations

Early detection of lung cancer: Protein biomarkers in exhaled air

Date:
February 9, 2011
Source:
Fraunhofer-Gesellschaft
Summary:
The earlier cancers can be detected, the better the chances of a cure. Researchers are now working to develop a new diagnostics platform with which the illness can be diagnosed in its early stages, even during a visit to the general practitioner: protein biomarkers in exhaled air divulge the presence of pathological cells in the lung.

The earlier cancers can be detected, the better the chances of a cure. Researchers are now working to develop a new diagnostics platform with which the illness can be diagnosed in its early stages, even during a visit to the general practitioner: protein biomarkers in exhaled air divulge the presence of pathological cells in the lung.

Lung tumors are the number one cause of death among cancer patients, and one cancer in three is lung cancer. Each year, there are 50,000 new cases of the disease in Germany alone. The earlier a tumor can be detected, the greater the chance of healing the patient. But early detection is difficult. In its initial stages, the tumor-related complaints resemble chronic inflammatory reactions.

To get a more complete diagnosis, the patient must undergo an X-ray examination or an bronchoscopy. The last procedure often involves irritation of the lung or removal of tissue samples and, as a result, it is particularly unpleasant for the patient undergoing the procedure.

In recent years, scientists at the Fraunhofer Institute for Cell Therapy and Immunology IZI in Leipzig have teamed up with colleagues at the University Clinic of Leipzig to develop a procedure that can detect special protein biomarkers in exhaled air. The presence of biomarkers suggests the presence of tumor cells in the lung. In a project sponsored by the Federal Ministry of Education and Research (BMBF), the specialists want to work with partners in industry -- two medium-sized companies in the regional -- to produce a first prototype that can then be further developed into a diagnostic tool that can be used in practice.

"Since 2006, working with the working groups of Professor Hubert Wirtz and Professor Ulrich Sack of the University Clinic, we first identified various biomarkers that are particularly well-suited for the identification of lung-cancer cells," notes Dr. Jörg Lehmann, head of the Cell Engineering/GLP Unit at IZI. "The main difficulty lies in finding a reliable way to distinguish cancer from chronic inflammatory disease."

The researchers have developed a laboratory method for reliably identifying biomarkers specific to lung cancer in special samples of exhaled air. To accomplish this, the patient must breathe into a piece of equipment for roughly 20 minutes. The exhaled breath condensate is then evaporated. Biomarkers are detected by means of special antibodies that recognize substances such as the protein VEGF. This protein is responsible for stimulating the growth of new blood vessels. This laboratory method is still too "elaborate and expensive" for normal everyday use, the scientist adds.

"Working in our joint project, the goal for the next two years is to produce a prototype that will then be validated in a clinical-diagnostic study and further developed to the production stage," Lehmann says.

In their new testing platform, the scientists have actually applied two new developments: in addition to the method enlisting protein biomarkers to identify cancer cells, they also make use of the antibody specially developed for this procedure. This way, within just a few years, every physician investigating a suspicion of lung cancer can use the diagnostic platform right in his or her practice to test whether there really is a tumor and quickly initiate treatment.


Story Source:

The above story is based on materials provided by Fraunhofer-Gesellschaft. Note: Materials may be edited for content and length.


Cite This Page:

Fraunhofer-Gesellschaft. "Early detection of lung cancer: Protein biomarkers in exhaled air." ScienceDaily. ScienceDaily, 9 February 2011. <www.sciencedaily.com/releases/2011/02/110202082811.htm>.
Fraunhofer-Gesellschaft. (2011, February 9). Early detection of lung cancer: Protein biomarkers in exhaled air. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2011/02/110202082811.htm
Fraunhofer-Gesellschaft. "Early detection of lung cancer: Protein biomarkers in exhaled air." ScienceDaily. www.sciencedaily.com/releases/2011/02/110202082811.htm (accessed September 22, 2014).

Share This



More Health & Medicine News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) — Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) — Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) — A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) — The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins