Featured Research

from universities, journals, and other organizations

Profiling malaria-causing parasites

Date:
February 7, 2011
Source:
Journal of Clinical Investigation
Summary:
The majority of fatal cases of malaria are caused by infection with the parasite Plasmodium falciparum. Most at risk are young children and women who are pregnant. Researchers have now developed an approach to profile P. falciparum parasites in such a way that they were able to identify parasite genes associated with severe infection, information that they hope will lead to the characterization of biomarkers of disease severity and targets for new intervention strategies.

The majority of fatal cases of malaria are caused by infection with the parasite Plasmodium falciparum. Most at risk are young children and women who are pregnant. A team of researchers, led by Patrick Duffy, at the National Institutes of Health, Rockville, has now developed an approach to profile P. falciparum parasites in such a way that they are able to identify parasite genes associated with severe infection.

Related Articles


In the study, they identified a distinct subset of genes in parasites infecting pregnant women, including a gene whose protein product is already known to be important for severe disease in these at risk patients and is a well-established pregnancy malaria vaccine candidate. They also identified a subset of genes that distinguished parasites infecting children from those infecting pregnant women. The team hopes that this information will provide new understanding of the nature of severe childhood malaria.

Future experiments will attempt to validate the protein products of these genes as biomarkers of disease severity and targets for new intervention strategies.

The research appears in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. marissa Vignali, Christopher D. Armour, Jingyang Chen, Robert Morrison, John C. Castle, Matthew C. Biery, Heather Bouzek, Wonjong Moon, Tomas Babak, Michal Fried, Christopher K. Raymond and Patrick E. Duffy. NSR-seq transcriptional profiling enables identification of a gene signature of Plasmodium falciparum parasites infecting children. Journal of Clinical Investigation, 2011; DOI: 10.1172/JCI43457

Cite This Page:

Journal of Clinical Investigation. "Profiling malaria-causing parasites." ScienceDaily. ScienceDaily, 7 February 2011. <www.sciencedaily.com/releases/2011/02/110207122011.htm>.
Journal of Clinical Investigation. (2011, February 7). Profiling malaria-causing parasites. ScienceDaily. Retrieved April 1, 2015 from www.sciencedaily.com/releases/2011/02/110207122011.htm
Journal of Clinical Investigation. "Profiling malaria-causing parasites." ScienceDaily. www.sciencedaily.com/releases/2011/02/110207122011.htm (accessed April 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, April 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Wound-Healing Laser Soon to Be a Reality Israeli Scientist

Reuters - Innovations Video Online (Apr. 1, 2015) Israeli scientists says laser bonding of tissue allows much faster healing and less scarring. Amy Pollock has more. Video provided by Reuters
Powered by NewsLook.com
Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

Liberia Sees Resurgence of Drug Trafficking as Ebola Wanes

AFP (Apr. 1, 2015) The governments of Liberia and Sierra Leone have been busy fighting the menace created by the deadly Ebola virus, but illicit drug lords have taken advantage of the situation to advance the drug trade. Duration: 01:12 Video provided by AFP
Powered by NewsLook.com
Stigma Stalks India's Leprosy Sufferers as Disease Returns

Stigma Stalks India's Leprosy Sufferers as Disease Returns

AFP (Apr. 1, 2015) The Indian government declared victory over leprosy in 2005, but the disease is making a comeback in some parts of the country, with more than a hundred thousand lepers still living in colonies, shunned from society. Duration: 02:41 Video provided by AFP
Powered by NewsLook.com
7-Year-Old Girl Gets 3-D Printed 'robohand'

7-Year-Old Girl Gets 3-D Printed 'robohand'

AP (Mar. 31, 2015) Although she never had much interest in prosthetic limbs before, Faith Lennox couldn&apos;t wait to slip on her new robohand. The 7-year-old, who lost part of her left arm when she was a baby, grabbed it as soon as it came off a 3-D printer. (March 31) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins