Featured Research

from universities, journals, and other organizations

Dramatic improvement in Parkinson disease symptoms following intranasal delivery of stem cells to rat brains

Date:
February 9, 2011
Source:
Mary Ann Liebert, Inc., Publishers
Summary:
Successful intranasal delivery of stem cells to the brains of rats with Parkinson disease yielded significant improvement in motor function and reversed the dopamine deficiency characteristic of the disease. The promising findings highlight the potential for a noninvasive approach to cell therapy delivery in Parkinson disease -- a safer and effective alternative to surgical transplantation of stem cells.

Successful intranasal delivery of stem cells to the brains of rats with Parkinson disease yielded significant improvement in motor function and reversed the dopamine deficiency characteristic of the disease.

The promising findings, reported in Rejuvenation Research, a peer-reviewed journal published by Mary Ann Liebert, Inc. highlight the potential for a noninvasive approach to cell therapy delivery in Parkinson disease-a safer and effective alternative to surgical transplantation of stem cells.

In this groundbreaking study, mesenchymal stem cells (MSCs) delivered via the nose preferentially migrated to the brain and were able to survive for at least 6 months. Substantial improvement in motor function -- up to 68% of normal -- was reported in the MSC-treated rat model of Parkinson disease. Levels of the neurotransmitter dopamine were significantly higher in affected rat brain regions exposed to MSCs compared to the non-treated brain regions, reported Lusine Danielyan and an international team of researchers from University Hospital of Tübingen, University of Göttingen Medical School, and University of Tübingen (Stuttgart, Germany; HealthPartners Research Foundation, St. Paul, MN; German University in Cairo, Egypt; Harvard University, Cambridge, MA; Institute of Molecular Biology NAS RA, Yerevan, Armenia; and Geneva University Hospital, Switzerland.

The authors explain that intranasal delivery of MSCs avoids the tissue trauma and related inflammation and brain swelling associated with surgical implantation of therapeutic stem cells. Importantly, this noninvasive delivery method would also make it possible to provide repeated stem cell treatments over time.


Story Source:

The above story is based on materials provided by Mary Ann Liebert, Inc., Publishers. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lusine Danielyan, Richard Schäfer, Andreas von Ameln-Mayerhofer, Felix Bernhard, Stephan Verleysdonk, Marine Buadze, Ali Lourhmati, Tim Klopfer, Felix Schaumann, Barbara Schmid, Christoph Koehle, Barbara Proksch, Robert Weissert, Holger M. Reichardt, Jens van den Brandt, Gayane H. Buniatian, Matthias Schwab, Christoph H. Gleiter, William H. Frey Ii. Therapeutic Efficacy of Intranasally Delivered Mesenchymal Stem Cells in a Rat Model of Parkinson Disease. Rejuvenation Research, 2011; 110203071223079 DOI: 10.1089/rej.2010.1130

Cite This Page:

Mary Ann Liebert, Inc., Publishers. "Dramatic improvement in Parkinson disease symptoms following intranasal delivery of stem cells to rat brains." ScienceDaily. ScienceDaily, 9 February 2011. <www.sciencedaily.com/releases/2011/02/110208163504.htm>.
Mary Ann Liebert, Inc., Publishers. (2011, February 9). Dramatic improvement in Parkinson disease symptoms following intranasal delivery of stem cells to rat brains. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2011/02/110208163504.htm
Mary Ann Liebert, Inc., Publishers. "Dramatic improvement in Parkinson disease symptoms following intranasal delivery of stem cells to rat brains." ScienceDaily. www.sciencedaily.com/releases/2011/02/110208163504.htm (accessed October 20, 2014).

Share This



More Health & Medicine News

Monday, October 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) — The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) — An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) — Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Fauci: Ebola Protocols to Focus on Training

Fauci: Ebola Protocols to Focus on Training

AP (Oct. 20, 2014) — Dr. Anthony Fauci, head of the National Institute of Allergy and Infectious Diseases, says he expects revised CDC protocols on Ebola to focus on training, observation and ensuring health care workers are more protected. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins