Featured Research

from universities, journals, and other organizations

Gene mutations linked to high blood pressure

Date:
February 11, 2011
Source:
Yale University
Summary:
Scientists have identified two novel genetic mutations that can trigger hypertension in up to a third of patients suffering from a common cause of severe high blood pressure.

High blood pressure may in some cases be caused by benign hormone-producing tumours of the adrenal cortex.
Credit: iStockphoto

Yale University researchers have identified two novel genetic mutations that can trigger hypertension in up to a third of patients suffering from a common cause of severe high blood pressure, they report in the Feb. 11 issue of the journal Science.

The findings are a major step in understanding the causes of high blood pressure, which afflicts one out of every three Americans, said Richard Lifton, Sterling Professor and chair of the Department of Genetics, professor of internal medicine and senior author of the paper. These findings may lead to a genetic screening test for this common cause of severe hypertension, he said.

Five to ten percent of patients with severe hypertension have tumors of the adrenal gland that produce a hormone called aldosterone. Removing these tumors can cure this form of hypertension. Sifting for clues by sequencing all of the genes from these tumors, and comparing their sequences to the patients' normal DNA, the researchers found that either one of two mutations of a single gene were found in 8 of 22 tumors studied. The investigators discovered that these mutations cause both aldosterone release and tumor formation by allowing the encoded protein, a potassium channel, to conduct sodium rather than only allowing potassium to pass through the channel.

In addition to causing these adrenal tumors, inherited mutations in the same gene were also found to be the cause of a rare familial form of severe hypertension.

The results underscore the value of whole exome sequencing, or decoding of all of a patient's genes rather than just a few suspect gene targets, said Lifton, who is an investigator for the Howard Hughes Medical Institute.

"This gene was not on anybody's list to sequence in an investigation of this disease," Lifton said. "We really hit the jackpot."

The project included investigators from Uppsaala University, New York Medical College and Henry Ford Hospital. Other authors affiliated with Yale are: Murim Choi, Ute I. Scholl, Peyman Bjφrklund, Bixiao Zhao, Carol Nelson-Williams, Weizhen Ji, Yoonsang Cho, Aniruddh Patel, Clara J. Men, Elias Lolis, David S. Geller, Shrikant Mane and Tobias Carling.


Story Source:

The above story is based on materials provided by Yale University. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Choi, U. I. Scholl, P. Yue, P. Bjorklund, B. Zhao, C. Nelson-Williams, W. Ji, Y. Cho, A. Patel, C. J. Men, E. Lolis, M. V. Wisgerhof, D. S. Geller, S. Mane, P. Hellman, G. Westin, G. Akerstrom, W. Wang, T. Carling, R. P. Lifton. K Channel Mutations in Adrenal Aldosterone-Producing Adenomas and Hereditary Hypertension. Science, 2011; 331 (6018): 768 DOI: 10.1126/science.1198785

Cite This Page:

Yale University. "Gene mutations linked to high blood pressure." ScienceDaily. ScienceDaily, 11 February 2011. <www.sciencedaily.com/releases/2011/02/110210141223.htm>.
Yale University. (2011, February 11). Gene mutations linked to high blood pressure. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2011/02/110210141223.htm
Yale University. "Gene mutations linked to high blood pressure." ScienceDaily. www.sciencedaily.com/releases/2011/02/110210141223.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) — The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) — The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) — The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) — In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins