Featured Research

from universities, journals, and other organizations

Protein could be new target to reduce damage after heart attack

Date:
February 25, 2011
Source:
American Heart Association
Summary:
A protein called fibronectin-EDA was linked to heart muscle damage after a heart attack in an animal study. Mice genetically altered to lack FN-EDA had less heart damage after a heart attack. Researchers suggest these findings hold potential for therapies to reduce or prevent heart muscle damage after a heart attack.

Scientists have identified a protein that plays a key role in debilitating changes that occur in the heart after a heart attack, according to research reported in Circulation Research: Journal of the American Heart Association.

These changes, or "remodeling" of the heart, often lead to fatal heart failure, which kills nearly 60,000 Americans each year. The findings suggest a possible future therapy for preventing or reducing heart muscle damage after a heart attack.

Researchers compared the effect of heart attacks in two groups of mice. One group was genetically engineered to lack fibronectin-EDA (FN-EDA), a protein that exists in the space surrounding cells and is important for processes such as cell migration and wound healing. The other mice were genetically normal.

After inducing a heart attack in the left coronary artery of each mouse, the team found that the hearts of mice lacking FN-EDA had less enlargement in the left ventricle, better pumping ability and less thickening of the heart muscle) compared to the control mice.

At the tissue level, the genetically engineered mice also had less inflammation; diminished activity of the enzymes metalloproteinase 2 and 9, which are involved in heart remodeling; and reduced myofibroblast transdifferentiation (a process in which cells near an injury site transform into myofibroblasts, which are cells that help heal injured tissue).

Bone marrow transplantation experiments revealed that the FN-EDA involved in the remodeling process came from the heart and not from cells circulating in the bloodstream.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fatih Arslan, Mirjam B. Smeets, Paul W. Riem Vis, Jacco C. Karper, Paul H. Quax, Lennart G. Bongartz, John H. Peters, Imo E. Hoefer, Pieter A. Doevendans, Gerard Pasterkamp, and Dominique P. de Kleijn. Lack of Fibronectin-EDA Promotes Survival and Prevents Adverse Remodeling and Heart Function Deterioration After Myocardial Infarction. Circ. Res.,, Feb 2011 DOI: 10.1161/CIRCRESAHA.110.224428

Cite This Page:

American Heart Association. "Protein could be new target to reduce damage after heart attack." ScienceDaily. ScienceDaily, 25 February 2011. <www.sciencedaily.com/releases/2011/02/110224161503.htm>.
American Heart Association. (2011, February 25). Protein could be new target to reduce damage after heart attack. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2011/02/110224161503.htm
American Heart Association. "Protein could be new target to reduce damage after heart attack." ScienceDaily. www.sciencedaily.com/releases/2011/02/110224161503.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins