Featured Research

from universities, journals, and other organizations

Human stem cells from fat tissue fuse with rat heart cells and beat

Date:
February 28, 2011
Source:
Federation of American Societies for Experimental Biology
Summary:
If Dr. Doolittle is famous for talking to animals, then here's a story that might make him hold his tongue: According to new research, scientists have successfully fused human stem cells derived from subcutaneous adipose (fat) tissue with muscle cells from rat hearts. Not only did these cells "talk" to form new muscle cells altogether, but they actually beat.

If Dr. Doolittle is famous for talking to animals, then here's a story that might make him hold his tongue: According to new research published online in The FASEB Journal, scientists have successfully fused human stem cells derived from subcutaneous adipose (fat) tissue with muscle cells from rat hearts. Not only did these cells "talk" to form new muscle cells altogether, but they actually beat.

"Recovery of regenerative cells located in the stromal vascular fraction of a patient's own subcutaneous tissue is relatively simple and can be used for self-healing," said Christopher Alt, Ph.D., a researcher involved in the work from the Department of Molecular Pathology at the University of Texas in Houston. "A patient's quality of life can be improved by application of those recovered regenerative cells to the heart, as well as to bone, tendons, non-healing wounds and joints."

Using newborn rats, scientists studied the combination of rat heart muscle cells (cardiomyocytes) and human adipose (fat) stem cells derived from human subcutaneous adipose tissue. They found that the two fused and formed new heart muscle cells with several nuclei. When kept in a culture environment, these cells beat. These new cells exhibited an ability to compensate for a loss of cardiomyocytes as following a myocardial infarction, via fusion with cardiomyocytes. Furthermore, this study shows that contrary to previous findings suggesting that genetic modification of certain embryonic genes in adult stem cells is required as a prerequisite for turning into heart cells, the human stem cells used in this study were not genetically modified.

"Much work is still ahead before this method can be applied to humans, but the hope is that this technique might eventually make heart transplants unnecessary," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This study not only shows the power of stem cell fusion technology, but also that cardiac regeneration is on the horizon."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. Metzele, C. Alt, X. Bai, Y. Yan, Z. Zhang, Z. Pan, M. Coleman, J. Vykoukal, Y.-H. Song, E. Alt. Human adipose tissue-derived stem cells exhibit proliferation potential and spontaneous rhythmic contraction after fusion with neonatal rat cardiomyocytes. The FASEB Journal, 2010; DOI: 10.1096/fj.09-153221

Cite This Page:

Federation of American Societies for Experimental Biology. "Human stem cells from fat tissue fuse with rat heart cells and beat." ScienceDaily. ScienceDaily, 28 February 2011. <www.sciencedaily.com/releases/2011/02/110228151907.htm>.
Federation of American Societies for Experimental Biology. (2011, February 28). Human stem cells from fat tissue fuse with rat heart cells and beat. ScienceDaily. Retrieved July 26, 2014 from www.sciencedaily.com/releases/2011/02/110228151907.htm
Federation of American Societies for Experimental Biology. "Human stem cells from fat tissue fuse with rat heart cells and beat." ScienceDaily. www.sciencedaily.com/releases/2011/02/110228151907.htm (accessed July 26, 2014).

Share This




More Health & Medicine News

Saturday, July 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins