Featured Research

from universities, journals, and other organizations

DREADD-ing your next meal

Date:
March 1, 2011
Source:
Journal of Clinical Investigation
Summary:
In the face of the growing obesity epidemic, much research has focused on the neuronal control of feeding behavior. Agouti-related protein (AgRP) neurons express three proteins that have been implicated in changes in energy balance, but the studies linking AgRP neurons to feeding behavior have produced mixed results.

In the face of the growing obesity epidemic, much research has focused on the neuronal control of feeding behavior. Agouti-related protein (AgRP) neurons express three proteins that have been implicated in changes in energy balance, but the studies linking AgRP neurons to feeding behavior have produced mixed results.

To directly analyze the role of AgRP neurons, Bradford Lowell and colleagues, at Beth Israel Deaconess Medical Center in Boston, used DREADD technology (designer receptors exclusively activated by designer drugs) to specifically control the activation and deactivation of this population in mice.

They found that chronic stimulation of AgRP neurons induced weight gain related to an increase in food intake.

Similarly, inhibition of this neuronal population inhibited food intake.

Furthermore, stimulation of AgRP neurons induced an intense, unrelenting food seeking behavior.

The researchers believe that this study demonstrates that AgRP neurons are critical regulators of a behavioral program that drives individuals to find and consume food.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Michael J. Krashes et al. Rapid, Reversible Activation of AgRP Neurons Drives Feeding Behavior in Mice. Journal of Clinical Investigation, March 2, 2011 DOI: 10.1172/JCI46229

Cite This Page:

Journal of Clinical Investigation. "DREADD-ing your next meal." ScienceDaily. ScienceDaily, 1 March 2011. <www.sciencedaily.com/releases/2011/03/110301122002.htm>.
Journal of Clinical Investigation. (2011, March 1). DREADD-ing your next meal. ScienceDaily. Retrieved April 21, 2014 from www.sciencedaily.com/releases/2011/03/110301122002.htm
Journal of Clinical Investigation. "DREADD-ing your next meal." ScienceDaily. www.sciencedaily.com/releases/2011/03/110301122002.htm (accessed April 21, 2014).

Share This



More Health & Medicine News

Monday, April 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nine-Month-Old Baby Can't Open His Mouth

Nine-Month-Old Baby Can't Open His Mouth

Newsy (Apr. 19, 2014) Nine-month-old Wyatt Scott was born with a rare disorder called congenital trismus, which prevents him from opening his mouth. Video provided by Newsy
Powered by NewsLook.com
'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins