Featured Research

from universities, journals, and other organizations

Why some people are apple-shaped and others are pear-shaped

Date:
March 15, 2011
Source:
University of Edinburgh
Summary:
Scientists have shed light on why some people are apple-shaped and others are pear-shaped. Researchers have pinpointed a protein that plays a part in how fat is stored in the body.

Scientists have shed light on why some people are apple-shaped and others are pear-shaped. Researchers at the University of Edinburgh have pinpointed a protein that plays a part in how fat is stored in the body.

Related Articles


The latest findings give greater understanding of how the protein works, which could help development of medicines to treat obesity.

Levels of the protein -- known as 11BetaHSD1 -- tend to be higher in the presence of an unhealthy type of body fat which tends to be stored around the torso -- typical of "apple-shapes."

Healthier fat, linked to lower levels of the protein, tends to be stored around the hips and is used more safely by the body as a source of energy -- typical of people who are "pear-shaped."

The study found that mice with the protein in their bodies were more likely to have unhealthy fat tissue after four weeks on a high fat diet, compared with mice without the protein.

Scientists are already looking at ways to make medicines that inhibit this protein, which is known to raise levels of hormones linked to obesity.

The research, published in the journal Diabetes was funded by the Wellcome Trust and British Heart Foundation.

Dr Nik Morton, of the University of Edinburgh's Centre for Cardiovascular Science, said: "This study opens up new avenues for research, and gives us a much better idea of why some fat in the body becomes unhealthy while other fat is safely stored for energy. Inflammation in of the unhealthy fat leads to reactions that can cause harm locally to tissues and affect the whole organism, promoting diabetes. Limiting the presence of this protein could help combat this."

As well as being more likely to be stored around vital organs in the torso, fat with higher levels of 11BetaHSD1 is considered to be unhealthy as it is associated with an over-reaction in the immune system.

Cells normally become inflamed in order to kill off an infection, but as there is no infection in the fat tissue the inflammation instead causes damage to healthy cells.


Story Source:

The above story is based on materials provided by University of Edinburgh. Note: Materials may be edited for content and length.


Journal Reference:

  1. M. Wamil, J. H. Battle, S. Turban, T. Kipari, D. Seguret, R. d. S. Peixoto, Y. B. Nelson, D. Nowakowska, D. Ferenbach, L. Ramage, K. E. Chapman, J. Hughes, D. R. Dunbar, J. R. Seckl, N. M. Morton. Novel Fat Depot-Specific Mechanisms Underlie Resistance to Visceral Obesity and Inflammation in 11-Hydroxysteroid Dehydrogenase Type 1-Deficient Mice. Diabetes, 2011; DOI: 10.2337/db10-0830

Cite This Page:

University of Edinburgh. "Why some people are apple-shaped and others are pear-shaped." ScienceDaily. ScienceDaily, 15 March 2011. <www.sciencedaily.com/releases/2011/03/110309091329.htm>.
University of Edinburgh. (2011, March 15). Why some people are apple-shaped and others are pear-shaped. ScienceDaily. Retrieved November 20, 2014 from www.sciencedaily.com/releases/2011/03/110309091329.htm
University of Edinburgh. "Why some people are apple-shaped and others are pear-shaped." ScienceDaily. www.sciencedaily.com/releases/2011/03/110309091329.htm (accessed November 20, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, November 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN Says It Will Scale Up Its Ebola Response

UN Says It Will Scale Up Its Ebola Response

AFP (Nov. 20, 2014) UN Resident Coordinator David McLachlan-Karr and WHO representative in the country Daniel Kertesz updated the media on the UN Ebola response on Wednesday. Duration: 00:51 Video provided by AFP
Powered by NewsLook.com
Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Takata Offers "sincerest Condolences" To Victims of Malfunctioning Airbag

Reuters - US Online Video (Nov. 20, 2014) U.S. Congress hears from a victim and company officials as it holds a hearing on the safety of Takata airbags after reports of injuries. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Obesity Costs Almost As Much As War And Terrorism

Obesity Costs Almost As Much As War And Terrorism

Newsy (Nov. 20, 2014) The newest estimate of the cost of obesity is pretty jarring — $2 trillion. But how did researchers get to that number? Video provided by Newsy
Powered by NewsLook.com
Ebola Crisis Affecting US Adoptions

Ebola Crisis Affecting US Adoptions

AP (Nov. 20, 2014) The Sanborn family had hoped they'd be able to bring home their 5-year-old adopted son from Liberia by now. But Ebola has forced them to wait. The boy is just one of thousands of orphans in West Africa who've been impacted by the deadly virus. (Nov. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins