Featured Research

from universities, journals, and other organizations

New research focuses on prion diseases

Date:
March 14, 2011
Source:
University of Kentucky
Summary:
New research may shed light on possible treatments for prion diseases.

New research by Chongsuk Ryou, researcher at the UK Sanders-Brown Center on Aging and professor of microbiology, immunology and molecular genetics in the UK College of Medicine, may shed light on possible treatments for prion diseases.

Related Articles


Prion diseases, which include Creutzfeldt-Jakob disease in humans and bovine spongiform encephalopathy ("mad cow" disease) in cattle, are caused by prions -- unconventional pathogens composed of infectious protein particles and resistant to conventional sterilization procedures. Presently there is no known agent or procedure that can halt or reverse damage caused by prion disease. Ryou and colleagues, however, have demonstrated through recent work that polymers of amino acid lysine (polylysines) are able to block propagation of prions by targeting plasminogen -- a substance that stimulates the multiplication of prions. In test tubes and cultured cells, polylysines halted the spread of prions.

Furthermore, in an animal model of prion disease, mice treated with polylysines displayed symptoms later, survived longer and showed lower levels of prions in their brains than did untreated mice.

"Our study suggests that polylysine is a potential anti-prion agent and validates plasminogen as a therapeutic target to combat prion disease," said Ryou.


Story Source:

The above story is based on materials provided by University of Kentucky. Note: Materials may be edited for content and length.


Journal Reference:

  1. Chongsuk Ryou, William B. Titlow, Charles E. Mays, Younsoo Bae, Sehun Kim. The suppression of prion propagation using poly-l-lysine by targeting plasminogen that stimulates prion protein conversion. Biomaterials, 2011; 32 (11): 3141 DOI: 10.1016/j.biomaterials.2011.01.017

Cite This Page:

University of Kentucky. "New research focuses on prion diseases." ScienceDaily. ScienceDaily, 14 March 2011. <www.sciencedaily.com/releases/2011/03/110314163602.htm>.
University of Kentucky. (2011, March 14). New research focuses on prion diseases. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/03/110314163602.htm
University of Kentucky. "New research focuses on prion diseases." ScienceDaily. www.sciencedaily.com/releases/2011/03/110314163602.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
The Hottest Food Trends for 2015

The Hottest Food Trends for 2015

Buzz60 (Dec. 17, 2014) Urbanspoon predicts whicg food trends will dominate the culinary scene in 2015. Mara Montalbano (@maramontalbano) has the story. Video provided by Buzz60
Powered by NewsLook.com
Rover Finds More Clues About Possible Life On Mars

Rover Finds More Clues About Possible Life On Mars

Newsy (Dec. 17, 2014) NASA's Curiosity rover detected methane on Mars and organic compounds on the surface, but it doesn't quite prove there was life ... yet. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins