Featured Research

from universities, journals, and other organizations

Researchers mimic body's own healing potential to create personalized therapies for inflammation

Date:
April 4, 2011
Source:
Queen Mary, University of London
Summary:
Scientists have found a way of mimicking the body's natural mechanism of fighting inflammation. The discovery paves the way for new personalized treatments to target uncontrolled inflammation that need not rely on synthetic biomaterials, therefore reducing potential toxicity.

Scientists at Barts and The London School of Medicine and Dentistry and Harvard Medical School, Boston have found a way of mimicking the body's natural mechanism of fighting inflammation. During inflammation cells release very small particles termed 'microparticles' that retain features of their parent cell. The scientists discovered that certain microparticles were beneficial to health, and that these microparticles contained anti-inflammatory lipids, which help terminate inflammation and return the body to its normal balance.

Related Articles


The discovery, featured online in the current edition of the Journal of Immunology, paves the way for new personalized treatments to target uncontrolled inflammation that need not rely on synthetic biomaterials, therefore reducing potential toxicity.

Inflammation of joints and muscles is implicated in many human diseases including cardiovascular disease, arthritis and temporomandibular disorders and its treatment remains an unmet medical need.

Led by Dr Lucy V Norling (a Foundation Fellow of the Arthritis Research UK), researchers from the William Harvey Research Institute at Barts and The London School of Medicine and Dentistry and Harvard Medical School (laboratory of Professor CN Serhan) investigated the properties of microparticles during inflammatory episodes showing them to contain beneficial lipids (fat molecules) that are precursors for compounds that stimulate the resolution of an inflammatory episode. The researchers then mimicked this natural communication process to make a new personalized delivery system for anti-inflammatory therapeutics based on natural human microparticles instead of synthetic biomaterials, which bring adverse immunotoxic effects.

The many benefits of these humanized particles, coined 'nano-proresolving medicines' are that they can be loaded with anti-inflammatories (e.g. resolvins or other small molecules) to enhance their protective bioactions.

Dr Norling said: "These results uncover a novel way of targeting anti-inflammatories therapeutics to the site of inflammation using a natural delivery system. I think this new mode of delivery could have application for numerous inflammatory diseases including those of the joint such as arthritis and temporomandibular disorders. "


Story Source:

The above story is based on materials provided by Queen Mary, University of London. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. V. Norling, M. Spite, R. Yang, R. J. Flower, M. Perretti, C. N. Serhan. Cutting Edge: Humanized Nano-Proresolving Medicines Mimic Inflammation-Resolution and Enhance Wound Healing. The Journal of Immunology, 2011; DOI: 10.4049/jimmunol.1003865

Cite This Page:

Queen Mary, University of London. "Researchers mimic body's own healing potential to create personalized therapies for inflammation." ScienceDaily. ScienceDaily, 4 April 2011. <www.sciencedaily.com/releases/2011/04/110404111048.htm>.
Queen Mary, University of London. (2011, April 4). Researchers mimic body's own healing potential to create personalized therapies for inflammation. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2011/04/110404111048.htm
Queen Mary, University of London. "Researchers mimic body's own healing potential to create personalized therapies for inflammation." ScienceDaily. www.sciencedaily.com/releases/2011/04/110404111048.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins