Featured Research

from universities, journals, and other organizations

Extreme weight gain raises risk for recurrence among breast cancer survivors

Date:
April 5, 2011
Source:
American Association for Cancer Research
Summary:
Breast cancer survivors who experience extreme weight gain have an increased risk of death after breast cancer diagnosis, according to new research. Moderate weight gain did not affect breast cancer outcomes.

Breast cancer survivors who experience extreme weight gain have an increased risk of death after breast cancer diagnosis. Moderate weight gain did not affect breast cancer outcomes. These study results were presented at the AACR 102nd Annual Meeting 2011, held in Orlando, Florida, April 2-6.

The investigation, which looked at the association of post-diagnosis weight gain and breast cancer outcomes, was conducted by researchers at Kaiser Permanente in Northern California. Data for the study came from the After Breast Cancer (ABC) Pooling Project, which includes 18,336 breast cancer survivors from four prospective cohorts -- three in the United States and one in Shanghai, China.

Participants were diagnosed with invasive primary breast cancer between 1976 and 2006; their ages ranged from 20 to 83 years. Weight and body mass index (BMI) were assessed 18 to 48 months after diagnosis and were compared with each woman's pre-diagnosis weight.

"Most women are not gaining a large amount of weight following breast cancer diagnosis," said lead researcher Bette Caan, Dr.P.H., senior research scientist at the Kaiser Permanente Division of Research. "But our analysis of the pooled data showed an association with poorer outcomes overall for those who do."

While extreme weight gain occurred in 16 percent of the women overall, 19.4 percent of women with a BMI lower than 25 before diagnosis fell into this category. Breast cancer survivors who gained the most (10 percent or more over their pre-diagnosis weight was considered extreme) were 14 percent more likely to experience a cancer recurrence compared with women whose weight remained stable (within 5 percent of pre-diagnosis weight) following diagnosis.

"Women tend to worry about gaining weight after a breast cancer diagnosis," said Caan. "But it's actually only the larger weight gains that increase the risk of poor outcomes."

Moderate weight gain (a 5 to 10 percent increase post-diagnosis) was also more common among normal or underweight women, but was unrelated to breast cancer outcomes. Only 11.1 percent of women who were overweight or obese before diagnosis had extreme weight gains after their diagnosis.

Women who were leaner to begin with at diagnosis (BMI lower than 25) and who later gained 10 percent or more had a 25 percent higher risk of cancer death and also had a higher risk of recurrence. The risk of overall death was also greater for women whose tumors were ER-positive.

Continued research is needed to understand those women most at risk for extreme weight gain and those whose weight gain puts them at risk for poorer cancer outcomes, according to Caan.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Extreme weight gain raises risk for recurrence among breast cancer survivors." ScienceDaily. ScienceDaily, 5 April 2011. <www.sciencedaily.com/releases/2011/04/110405082614.htm>.
American Association for Cancer Research. (2011, April 5). Extreme weight gain raises risk for recurrence among breast cancer survivors. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/04/110405082614.htm
American Association for Cancer Research. "Extreme weight gain raises risk for recurrence among breast cancer survivors." ScienceDaily. www.sciencedaily.com/releases/2011/04/110405082614.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins