Featured Research

from universities, journals, and other organizations

Extreme weight gain raises risk for recurrence among breast cancer survivors

Date:
April 5, 2011
Source:
American Association for Cancer Research
Summary:
Breast cancer survivors who experience extreme weight gain have an increased risk of death after breast cancer diagnosis, according to new research. Moderate weight gain did not affect breast cancer outcomes.

Breast cancer survivors who experience extreme weight gain have an increased risk of death after breast cancer diagnosis. Moderate weight gain did not affect breast cancer outcomes. These study results were presented at the AACR 102nd Annual Meeting 2011, held in Orlando, Florida, April 2-6.

Related Articles


The investigation, which looked at the association of post-diagnosis weight gain and breast cancer outcomes, was conducted by researchers at Kaiser Permanente in Northern California. Data for the study came from the After Breast Cancer (ABC) Pooling Project, which includes 18,336 breast cancer survivors from four prospective cohorts -- three in the United States and one in Shanghai, China.

Participants were diagnosed with invasive primary breast cancer between 1976 and 2006; their ages ranged from 20 to 83 years. Weight and body mass index (BMI) were assessed 18 to 48 months after diagnosis and were compared with each woman's pre-diagnosis weight.

"Most women are not gaining a large amount of weight following breast cancer diagnosis," said lead researcher Bette Caan, Dr.P.H., senior research scientist at the Kaiser Permanente Division of Research. "But our analysis of the pooled data showed an association with poorer outcomes overall for those who do."

While extreme weight gain occurred in 16 percent of the women overall, 19.4 percent of women with a BMI lower than 25 before diagnosis fell into this category. Breast cancer survivors who gained the most (10 percent or more over their pre-diagnosis weight was considered extreme) were 14 percent more likely to experience a cancer recurrence compared with women whose weight remained stable (within 5 percent of pre-diagnosis weight) following diagnosis.

"Women tend to worry about gaining weight after a breast cancer diagnosis," said Caan. "But it's actually only the larger weight gains that increase the risk of poor outcomes."

Moderate weight gain (a 5 to 10 percent increase post-diagnosis) was also more common among normal or underweight women, but was unrelated to breast cancer outcomes. Only 11.1 percent of women who were overweight or obese before diagnosis had extreme weight gains after their diagnosis.

Women who were leaner to begin with at diagnosis (BMI lower than 25) and who later gained 10 percent or more had a 25 percent higher risk of cancer death and also had a higher risk of recurrence. The risk of overall death was also greater for women whose tumors were ER-positive.

Continued research is needed to understand those women most at risk for extreme weight gain and those whose weight gain puts them at risk for poorer cancer outcomes, according to Caan.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Extreme weight gain raises risk for recurrence among breast cancer survivors." ScienceDaily. ScienceDaily, 5 April 2011. <www.sciencedaily.com/releases/2011/04/110405082614.htm>.
American Association for Cancer Research. (2011, April 5). Extreme weight gain raises risk for recurrence among breast cancer survivors. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2011/04/110405082614.htm
American Association for Cancer Research. "Extreme weight gain raises risk for recurrence among breast cancer survivors." ScienceDaily. www.sciencedaily.com/releases/2011/04/110405082614.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins