Featured Research

from universities, journals, and other organizations

Antibiotic resistance spreads rapidly between bacteria

Date:
April 13, 2011
Source:
University of Gothenburg
Summary:
The part of bacterial DNA that often carries antibiotic resistance is a master at moving between different types of bacteria and adapting to widely differing bacterial species, say researchers in Sweden.

Antibiotic resistance-carrying plasmids from different bacteria can meet and exchange genetic material. The result is plasmids consisting of genes that have each been adapted to different bacterial species. This facilitates further adaptation and mobility, and consequently also the spread of antibiotic resistance between different bacterial species.
Credit: Bjφrn Norberg

The part of bacterial DNA that often carries antibiotic resistance is a master at moving between different types of bacteria and adapting to widely differing bacterial species, shows a study made by a research team at the University of Gothenburg in cooperation with Chalmers University of Technology.

The results are published in an article in the scientific journal Nature Communications.

More and more bacteria are becoming resistant to our common antibiotics, and to make matters worse, more and more are becoming resistant to all known antibiotics. The problem is known as multi-resistance, and is generally described as one of the most significant future threats to public health Antibiotic resistance can arise in bacteria in our environment and in our bodies. Antibiotic resistance can then be transferred to the bacteria that cause human diseases, even if the bacteria are not related to each other.

A large proportion of gene transfer between bacteria takes place with the aid of what are known as conjugative plasmids, a part of the bacterial DNA. A plasmid can only exist and multiply inside a cell, where it uses the cell's machinery, but can then be transferred to another cell and in that way spread between bacteria.

The research team has studied a group of the known carriers of antibiotic resistance genes: IncP-1 plasmids. Using advanced DNA analysis, the researchers have succeeded in mapping the origin of different IncP-1 plasmids and their mobility between different bacterial species. "Our results show that plasmids from the IncP-1 group have existed in, and adapted to, widely differing bacteria. They have also recombined, which means that a single plasmid can be regarded as a composite jigsaw puzzle of genes, each of which has adapted to different bacterial species," says Peter Norberg, a researcher in the Institute of Biomedicine at the University of Gothenburg. This indicates very good adaptability and suggests that these plasmids can move relatively freely between, and thrive in, widely differing bacterial species.

"IncP-1 plasmids are very potent 'vehicles' for transporting antibiotic resistance genes between bacterial species. Therefore, it does not matter much in what environment, in what part of the world, or in what bacterial species antibiotic resistance arises. Resistance genes could relatively easily be transported from the original environment to bacteria that infect humans, through IncP-1 plasmids, or other plasmids with similar properties, as 'vehicles'," says Professor Malte Hermansson of the Department of Cell and Molecular Biology at the University of Gothenburg.

It has been known for some time that plasmids are important in the spread of antibiotic resistance. The research team's findings show that IncP-1 plasmids can move, and have moved, between widely differing bacterial species and in addition have interacted directly with one another, which can increase the potential for gene spreading.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Journal Reference:

  1. Peter Norberg, Maria Bergstrφm, Vinay Jethava, Devdatt Dubhashi, Malte Hermansson. The IncP-1 plasmid backbone adapts to different host bacterial species and evolves through homologous recombination. Nature Communications, 2011; 2: 272 DOI: 10.1038/ncomms1267

Cite This Page:

University of Gothenburg. "Antibiotic resistance spreads rapidly between bacteria." ScienceDaily. ScienceDaily, 13 April 2011. <www.sciencedaily.com/releases/2011/04/110411163918.htm>.
University of Gothenburg. (2011, April 13). Antibiotic resistance spreads rapidly between bacteria. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2011/04/110411163918.htm
University of Gothenburg. "Antibiotic resistance spreads rapidly between bacteria." ScienceDaily. www.sciencedaily.com/releases/2011/04/110411163918.htm (accessed October 22, 2014).

Share This



More Plants & Animals News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Cadaver Dogs Aid Search for More Victims of Suspected Indiana Serial Killer

Cadaver Dogs Aid Search for More Victims of Suspected Indiana Serial Killer

Reuters - US Online Video (Oct. 21, 2014) — Police in Gary, Indiana are using cadaver dogs to search for more victims after a suspected serial killer confessed to killing at least seven women. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
White Lion Cubs Unveiled to the Public

White Lion Cubs Unveiled to the Public

Reuters - Light News Video Online (Oct. 21, 2014) — Visitors to Belgrade zoo meet a pair of three-week-old lion cubs for the first time. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
'Cadaver Dog' Sniffs out Human Remains

'Cadaver Dog' Sniffs out Human Remains

AP (Oct. 21, 2014) — Where's a body buried? Buster's nose can often tell you. He's a cadaver dog, specially trained to find human remains and increasingly being used by law enforcement and accepted in courts. These dogs are helping solve even decades-old mysteries. (Oct. 21) Video provided by AP
Powered by NewsLook.com
White Lion Cubs Born in Belgrade Zoo

White Lion Cubs Born in Belgrade Zoo

AFP (Oct. 20, 2014) — Two white lion cubs, an extremely rare subspecies of the African lion, were recently born at Belgrade Zoo. They are being bottle fed by zoo keepers after they were rejected by their mother after birth. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins