Featured Research

from universities, journals, and other organizations

New perspectives on ion selectivity

Date:
April 25, 2011
Source:
Rockefeller University Press
Summary:
A new series of articles examines the ion selectivity of cation-selective channels and transporters.

(Left) K+ ion (magenta sphere) is shown bound in the S2 site of the selectivity filter (green ribbon). The backbone carbonyl groups of the S2 site are shown as spheres. (Right) View looking down the pore axis. Atoms are shown in space-filling format.
Credit: Dixit, P.D., and D. Asthagiri. 2011. J. Gen. Physiol. doi:10.1085/jgp.201010533.

The latest Perspectives in General Physiology series examines the ion selectivity of cation-selective channels and transporters.

The series appears in the May 2011 issue of the Journal of General Physiology (www.jgp.org).

According to Perspectives Editor Olaf Andersen in his introduction, a key tool in most recent studies on ion selectivity has been the so-called "toy models," which emphasize the fluid-like features of the selectivity filter and allow for the isolation of key features. Although proteins may indeed be fluid-like at small-length scales, however, they show considerable rigidity at longer-length scales. Thus, while toy models allow for important new insights, the goal is to transfer this knowledge into understanding the selectivity of the bilayer-spanning channels. This remains a challenge as it becomes necessary to consider not only the equilibrium situations but also the kinetics, and the competition among the permeant ions as they strive to make it through the channel.

As demonstrated by the Perspectives contributors in this issue, the questions surrounding ion selectivity can be approached from different, complementary directions. Alam and Jiang focus on what can be deduced from crystal structures; Nimigean and Allen consider what can be learned from a combined electrophysiological, crystallographic, and computational approach; and the last three contributors -- Roux et al., Dixit and Asthagiri, and Varma et al. (appearing in the June 2011 issue of the JGP) -- consider different theoretical and computational approaches based on MD simulations and quasi-chemical theory, including the use of simple "toy" models, to identify the mechanisms underlying ion selectivity.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal References:

  1. O. S. Andersen. Perspectives on: Ion selectivity. The Journal of General Physiology, 2011; 137 (5): 393 DOI: 10.1085/jgp.201110651
  2. A. Alam, Y. Jiang. Perspectives on: Ion selectivity: Structural studies of ion selectivity in tetrameric cation channels. The Journal of General Physiology, 2011; 137 (5): 397 DOI: 10.1085/jgp.201010546
  3. C. M. Nimigean, T. W. Allen. Perspectives on: Ion selectivity: Origins of ion selectivity in potassium channels from the perspective of channel block. The Journal of General Physiology, 2011; 137 (5): 405 DOI: 10.1085/jgp.201010551
  4. B. Roux, S. Berneche, B. Egwolf, B. Lev, S. Y. Noskov, C. N. Rowley, H. Yu. Perspectives on: Ion selectivity: Ion selectivity in channels and transporters. The Journal of General Physiology, 2011; 137 (5): 415 DOI: 10.1085/jgp.201010577
  5. P. D. Dixit, D. Asthagiri. Perspectives on: Ion selectivity: Thermodynamics of ion selectivity in the KcsA K channel. The Journal of General Physiology, 2011; 137 (5): 427 DOI: 10.1085/jgp.201010533

Cite This Page:

Rockefeller University Press. "New perspectives on ion selectivity." ScienceDaily. ScienceDaily, 25 April 2011. <www.sciencedaily.com/releases/2011/04/110425135508.htm>.
Rockefeller University Press. (2011, April 25). New perspectives on ion selectivity. ScienceDaily. Retrieved July 24, 2014 from www.sciencedaily.com/releases/2011/04/110425135508.htm
Rockefeller University Press. "New perspectives on ion selectivity." ScienceDaily. www.sciencedaily.com/releases/2011/04/110425135508.htm (accessed July 24, 2014).

Share This




More Matter & Energy News

Thursday, July 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Creative Makeovers for Ugly Cellphone Towers

Creative Makeovers for Ugly Cellphone Towers

AP (July 24, 2014) Mobile phone companies and communities across the country are going to new lengths to disguise those unsightly cellphone towers. From a church bell tower to a flagpole, even a pencil, some towers are trying to make a point. (July 24) Video provided by AP
Powered by NewsLook.com
Robot Parking Valet Creates Stress-Free Travel

Robot Parking Valet Creates Stress-Free Travel

AP (July 23, 2014) 'Ray' the robotic parking valet at Dusseldorf Airport in Germany lets travelers to avoid the hassle of finding a parking spot before heading to the check-in desk. (July 23) Video provided by AP
Powered by NewsLook.com
Boeing Ups Outlook on 52% Profit Jump

Boeing Ups Outlook on 52% Profit Jump

Reuters - Business Video Online (July 23, 2014) Commercial aircraft deliveries rose seven percent at Boeing, prompting the aerospace company to boost full-year profit guidance- though quarterly revenues missed analyst estimates. Bobbi Rebell reports. Video provided by Reuters
Powered by NewsLook.com
Europe's Car Market on the Rebound?

Europe's Car Market on the Rebound?

Reuters - Business Video Online (July 23, 2014) Daimler kicks off a round of second-quarter earnings results from Europe's top carmakers with a healthy set of numbers - prompting hopes that stronger sales in Europe will counter weakness in emerging markets. Hayley Platt reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins