Featured Research

from universities, journals, and other organizations

Antibiotic may prove beneficial to preterm infant lung health, study suggests

Date:
April 27, 2011
Source:
University of Kentucky
Summary:
A new study shows promise for the use of azithromycin in treating Ureaplasma-colonized or infected premature infants to prevent bronchopulmonary dysplasia (BPD).

A study performed by University of Kentucky researchers shows promise for the use of azithromycin in treating Ureaplasma-colonized or infected premature infants to prevent bronchopulmonary dysplasia (BPD).

The study, published in Pediatric Pulmonology, showed subjects colonized or infected with the Ureaplasma bacteria developed BPD or died 73 percent of the time in the azithromycin-treated group, compared to 94 percent of the time in the placebo group.

Bronchopulmonary dysplasia is a chronic lung disorder characterized by inflammation and scarring in the lungs. It is common among premature infants, whose lungs are not fully developed before birth.

This disorder can lead to chronic lung damage or death. Many infants who survive are at a greater risk for having recurrent respiratory infections, such as pneumonia or bronchiolitis.

The presence of the Ureaplasma bacterium is a risk factor in developing BPD. This bacterium causes inflammation in the lungs and can also lead to meningitis, pneumonia or septicemia. It is passed on from mother to child. An estimated 80 percent of women are already colonized with it, and nearly 45 percent of extremely preterm infants are affected by it.

"Current preventative therapies for bronchopulmonary dysplasia are limited," said Dr. Hubert O. Ballard, the UK neonatologist leading the study. "Because the inflammation from a Ureaplasma infection often leads to BPD, and because this bacterium is so easily spread to infants from the mother, we sought to find out if the anti-inflammatory benefits of azithromycin could help prevent the disorder from developing."

The study was performed on a group of 220 infants admitted to the UK Neonatal Intensive Care Unit from September 2004 to August 2008. Enrollment criteria included a birth weight of less than 1,250 grams, the use of intermittent mechanical ventilation for fewer than 12 hours, and an age of under 72 hours.

Upon enrollment, each infact was randomized to receive azithromycin or a placebo for a total of six weeks. Infants testing positive for Ureaplasma were placed in a separate subgroup of the study.

Ballard, et al, previously published a pilot study that demonstrated a possible benefit of azithromycin prophylaxis in infants weighing less than 1,000 grams, but the original study excluded patients who tested positive for the Ureaplasma bacteria.

Neither the previous study nor the current study demonstrated a statistically significant benefit to using azithromycin therapy to prevent BPD in preterm infants who were not colonized or infected with Ureasplasma.

Though the results of the study show potential for preventing bronchopulmonary dysplasia in Ureaplasma-colonized or infected patients, Dr. Ballard stressed that a larger multi-centered trial is needed to properly assess the benefits of azithromycin for these subjects.

"Our research demonstrates the benefit of treating preterm infants with azithromycin who are colonized or infected with Ureaplasma. To date, this is the largest single-center study to evaluate azithromycin use in preterm infants," Ballard said. "However, further studies are required to evaluate azithromycin therapy for the routine treatment of Ureaplasma colonization/infection in the preterm population."


Story Source:

The above story is based on materials provided by University of Kentucky. Note: Materials may be edited for content and length.


Journal Reference:

  1. Hubert O. Ballard, Lori A. Shook, Philip Bernard, Michael I. Anstead, Robert Kuhn, Vicki Whitehead, Deb Grider, Timothy N. Crawford, Don Hayes. Use of azithromycin for the prevention of bronchopulmonary dysplasia in preterm infants: a randomized, double-blind, placebo controlled trial. Pediatric Pulmonology, 2011; 46 (2): 111 DOI: 10.1002/ppul.21352

Cite This Page:

University of Kentucky. "Antibiotic may prove beneficial to preterm infant lung health, study suggests." ScienceDaily. ScienceDaily, 27 April 2011. <www.sciencedaily.com/releases/2011/04/110426071023.htm>.
University of Kentucky. (2011, April 27). Antibiotic may prove beneficial to preterm infant lung health, study suggests. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2011/04/110426071023.htm
University of Kentucky. "Antibiotic may prove beneficial to preterm infant lung health, study suggests." ScienceDaily. www.sciencedaily.com/releases/2011/04/110426071023.htm (accessed July 28, 2014).

Share This




More Health & Medicine News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com
West Africa Gripped by Deadly Ebola Outbreak

West Africa Gripped by Deadly Ebola Outbreak

AFP (July 28, 2014) The worst-ever outbreak of the deadly Ebola epidemic grips west Africa, killing hundreds. Duration: 00:48 Video provided by AFP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
Google's Next Frontier: The Human Body

Google's Next Frontier: The Human Body

Newsy (July 27, 2014) Google is collecting genetic and molecular information to paint a picture of the perfectly healthy human. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins