Featured Research

from universities, journals, and other organizations

Cell division abnormality contributes to inflammation in COPD

Date:
May 15, 2011
Source:
American Thoracic Society
Summary:
Changes in the ability of lung cells to divide may play a role in initiating or prolonging lung tissue inflammation, a hallmark of chronic obstructive pulmonary disease, according to a new study.

Changes in the ability of lung cells to divide may play a role in initiating or prolonging lung tissue inflammation, a hallmark of chronic obstructive pulmonary disease (COPD), according to a study conducted by researchers in France.

The results were presented at the ATS 2011 International Conference in Denver.

"We found that lung tissue cells of patients with COPD had an impaired ability to divide, or had lost their ability to divide," said lead author Valerie Amsellem, MD, PhD, professor of medicine at the National Institute of Health and Medical Research (INSERM) in Creteil, France. "This phenomenon, called senescence, affects several types of cells that build the lung. In addition, we found that these cells change their behavior by producing different molecules that could contribute to inflammation."

COPD is associated with smoking and occurs much more commonly in individuals as they grow older. Dr. Amsellem wanted to determine if the aging process of cells contributes to the sustained lung inflammation associated with COPD.

During its normal life cycle, a cell will divide many times; however, its ability to divide decreases as it ages. This cellular aging process, or senescence, can vary by cell, and can also be affected by disease processes. In this study, the researchers looked specifically at endothelial cells, which border the tiny blood vessels in the lungs and create a barrier between blood and tissue.

Endothelial cells were collected from 15 patients with COPD and 15 age- and sex-matched control subjects, who were smokers but did not have COPD. Laboratory analysis of the cells revealed a higher percentage of senescent endothelial cells in patients with COPD when compared to controls. In addition, endothelial cells from COPD patients displayed accelerated senescence, meaning they lost their ability to divide compared to endothelial cells from control subjects. Senescent cells from COPD patients also produced greater numbers of molecules, which are associated with increased and persistent inflammation, than their control counterparts.

"We found that endothelial cells from the lungs of COPD patients displayed more characteristics of senescence than cells from patients not affected with COPD, and we also showed that it is the senescence of these cells that creates an inflammatory context that could contribute to lung inflammation which is seen in COPD," Dr. Amsellem said.

Although an increase in senescent characteristics was expected, Dr. Amsellem said the finding that the senescent process appeared to contribute to unresolved inflammation was not.

"We expected to find senescence characteristics in the cells of COPD patients," Dr. Amsellem said. "However, the fact that senescent endothelial cells released factors promoting sustained inflammation was a novel finding.

"The fact that it is the accelerated aging phenomenon of cells that contributes to inflammation will open a new therapeutic strategy to cure chronic inflammation in COPD disease," she added.

Future research will focus on strategies to limit senescence of cells associated with inflammation, and to understand how senescence of endothelial cells affects other cells involved in conditions, which may occur in patients with COPD, such as cardiovascular disease.


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Cell division abnormality contributes to inflammation in COPD." ScienceDaily. ScienceDaily, 15 May 2011. <www.sciencedaily.com/releases/2011/05/110515122455.htm>.
American Thoracic Society. (2011, May 15). Cell division abnormality contributes to inflammation in COPD. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2011/05/110515122455.htm
American Thoracic Society. "Cell division abnormality contributes to inflammation in COPD." ScienceDaily. www.sciencedaily.com/releases/2011/05/110515122455.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins