Featured Research

from universities, journals, and other organizations

Cell division abnormality contributes to inflammation in COPD

Date:
May 15, 2011
Source:
American Thoracic Society
Summary:
Changes in the ability of lung cells to divide may play a role in initiating or prolonging lung tissue inflammation, a hallmark of chronic obstructive pulmonary disease, according to a new study.

Changes in the ability of lung cells to divide may play a role in initiating or prolonging lung tissue inflammation, a hallmark of chronic obstructive pulmonary disease (COPD), according to a study conducted by researchers in France.

The results were presented at the ATS 2011 International Conference in Denver.

"We found that lung tissue cells of patients with COPD had an impaired ability to divide, or had lost their ability to divide," said lead author Valerie Amsellem, MD, PhD, professor of medicine at the National Institute of Health and Medical Research (INSERM) in Creteil, France. "This phenomenon, called senescence, affects several types of cells that build the lung. In addition, we found that these cells change their behavior by producing different molecules that could contribute to inflammation."

COPD is associated with smoking and occurs much more commonly in individuals as they grow older. Dr. Amsellem wanted to determine if the aging process of cells contributes to the sustained lung inflammation associated with COPD.

During its normal life cycle, a cell will divide many times; however, its ability to divide decreases as it ages. This cellular aging process, or senescence, can vary by cell, and can also be affected by disease processes. In this study, the researchers looked specifically at endothelial cells, which border the tiny blood vessels in the lungs and create a barrier between blood and tissue.

Endothelial cells were collected from 15 patients with COPD and 15 age- and sex-matched control subjects, who were smokers but did not have COPD. Laboratory analysis of the cells revealed a higher percentage of senescent endothelial cells in patients with COPD when compared to controls. In addition, endothelial cells from COPD patients displayed accelerated senescence, meaning they lost their ability to divide compared to endothelial cells from control subjects. Senescent cells from COPD patients also produced greater numbers of molecules, which are associated with increased and persistent inflammation, than their control counterparts.

"We found that endothelial cells from the lungs of COPD patients displayed more characteristics of senescence than cells from patients not affected with COPD, and we also showed that it is the senescence of these cells that creates an inflammatory context that could contribute to lung inflammation which is seen in COPD," Dr. Amsellem said.

Although an increase in senescent characteristics was expected, Dr. Amsellem said the finding that the senescent process appeared to contribute to unresolved inflammation was not.

"We expected to find senescence characteristics in the cells of COPD patients," Dr. Amsellem said. "However, the fact that senescent endothelial cells released factors promoting sustained inflammation was a novel finding.

"The fact that it is the accelerated aging phenomenon of cells that contributes to inflammation will open a new therapeutic strategy to cure chronic inflammation in COPD disease," she added.

Future research will focus on strategies to limit senescence of cells associated with inflammation, and to understand how senescence of endothelial cells affects other cells involved in conditions, which may occur in patients with COPD, such as cardiovascular disease.


Story Source:

The above story is based on materials provided by American Thoracic Society. Note: Materials may be edited for content and length.


Cite This Page:

American Thoracic Society. "Cell division abnormality contributes to inflammation in COPD." ScienceDaily. ScienceDaily, 15 May 2011. <www.sciencedaily.com/releases/2011/05/110515122455.htm>.
American Thoracic Society. (2011, May 15). Cell division abnormality contributes to inflammation in COPD. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2011/05/110515122455.htm
American Thoracic Society. "Cell division abnormality contributes to inflammation in COPD." ScienceDaily. www.sciencedaily.com/releases/2011/05/110515122455.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins