Featured Research

from universities, journals, and other organizations

Malaria risk reduced by genetic predisposition for cell suicide, study finds

Date:
May 20, 2011
Source:
Public Library of Science
Summary:
A human genetic variant associated with an almost 30 percent reduced risk of developing severe malaria has been identified. Scientists reveal that a variant at the FAS locus can prevent an excessive and potentially hazardous immune response in infected children.

A human genetic variant associated with an almost 30 percent reduced risk of developing severe malaria has been identified. Scientists from the Bernhard Nocht Institute for Tropical Medicine (BNITM), Hamburg, and Kumasi University, Ghana, reveal that a variant at the FAS locus can prevent an excessive and potentially hazardous immune response in infected children.

The study appears in the open-access journal PLoS Genetics on May 19.

Severe malaria is a major public health burden in Sub-Saharan Africa, where approximately one million individuals die each year as a result of infection with Plasmodium falciparum. Whereas adults in endemic areas develop some resistance to malaria, preventing severe complications, children under the age of five years can develop life-threatening forms of the disease. To date, the molecular mechanisms causing these manifestations are poorly understood.

FAS encodes for CD95, a molecule critically involved in the programmed death of some white blood cells. This candidate gene study, including more than 6,000 child subjects, details how a single nucleotide variant of FAS predisposes its carriers to a higher number of immune cells prone to suicide. These findings indicate that a genetic predisposition to an increased expression of CD95 may help to protect from severe malaria, possibly by rendering a type of white blood cell more susceptible to programmed cell death.

Kathrin Schuldt, co-author, said, "We believe that our study will help to unravel the mechanisms causing the fatal forms of malaria."


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kathrin Schuldt, Cosima C. Kretz, Christian Timmann, Jόrgen Sievertsen, Christa Ehmen, Claudia Esser, Wibke Loag, Daniel Ansong, Carmen Dering, Jennifer Evans, Andreas Ziegler, Jόrgen May, Peter H. Krammer, Tsiri Agbenyega, Rolf D. Horstmann. A −436C>A Polymorphism in the Human FAS Gene Promoter Associated with Severe Childhood Malaria. PLoS Genetics, 2011; 7 (5): e1002066 DOI: 10.1371/journal.pgen.1002066

Cite This Page:

Public Library of Science. "Malaria risk reduced by genetic predisposition for cell suicide, study finds." ScienceDaily. ScienceDaily, 20 May 2011. <www.sciencedaily.com/releases/2011/05/110519172912.htm>.
Public Library of Science. (2011, May 20). Malaria risk reduced by genetic predisposition for cell suicide, study finds. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/05/110519172912.htm
Public Library of Science. "Malaria risk reduced by genetic predisposition for cell suicide, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/05/110519172912.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) — Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) — Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) — At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Xtreme Eating: Your Daily Caloric Intake All On One Plate

Xtreme Eating: Your Daily Caloric Intake All On One Plate

Newsy (July 30, 2014) — The Center for Science in the Public Interest released its 2014 list of single meals with whopping calorie counts. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins