Featured Research

from universities, journals, and other organizations

Apparent genetic link to prostate cancer in African-American men determined

Date:
May 24, 2011
Source:
University of Southern California
Summary:
Some men of African descent may have a higher genetic risk of developing prostate cancer, according to new research. The genome-wide association study determined a marker of risk for prostate cancer in men of African descent, who tend to more susceptible to prostate cancer than men of non-African descent.

Some men of African descent may have a higher genetic risk of developing prostate cancer, according to research conducted at the Keck School of Medicine of the University of Southern California (USC).

The genome-wide association study, published in the journal Nature Genetics on May 22, determined a marker of risk for prostate cancer in men of African descent, who tend to more susceptible to prostate cancer than men of non-African descent. The research team was led by Christopher Haiman, ScD., at the USC Norris Comprehensive Cancer Center and Hospital, part of the Keck School.

"This is a novel risk locus for prostate cancer, and the first study of its kind conducted in men of African ancestry," said Haiman, associate professor in the Keck School Department of Preventive Medicine. "We have been trying to figure out why African American men have a greater risk for prostate cancer. These findings may help us better understand if there is a genetic contribution to disparities in risk for this common cancer."

The research looked at common risk alleles for prostate cancer in men of African descent to determine a possible reason for the high incidence of prostate cancer in this population. The research focused on approximately one million single nucleotide polymorphism (SNP) markers across the genome of 3,425 African-American men with prostate cancer and 3,290 African-American male controls. The research turned up a novel risk variant on chromosome 17q21. The frequency of this marker is 5 percent in men of African ancestry but is rare in other populations.

The discovery builds on findings several years ago by Haiman's team of a risk region on chromosome 8q24, which also contains clues as to why more men in this population are likely to develop prostate cancer.

The findings support the need for additional genome-wide investigations to locate risk markers that are common or rare, which may play a role in racial and ethnic disease disparities, Haiman said.

The research is part of the Multiethnic Cohort study (MEC), conducted between the Keck School and the University of Hawai'i, and funded by the National Cancer Institute.


Story Source:

The above story is based on materials provided by University of Southern California. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christopher A Haiman, Gary K Chen, William J Blot, Sara S Strom, Sonja I Berndt, Rick A Kittles, Benjamin A Rybicki, William B Isaacs, Sue A Ingles, Janet L Stanford, W Ryan Diver, John S Witte, Ann W Hsing, Barbara Nemesure, Timothy R Rebbeck, Kathleen A Cooney, Jianfeng Xu, Adam S Kibel, Jennifer J Hu, Esther M John, Serigne M Gueye, Stephen Watya, Lisa B Signorello, Richard B Hayes, Zhaoming Wang, Edward Yeboah, Yao Tettey, Qiuyin Cai, Suzanne Kolb, Elaine A Ostrander, Charnita Zeigler-Johnson, Yuko Yamamura, Christine Neslund-Dudas, Jennifer Haslag-Minoff, William Wu, Venetta Thomas, Glenn O Allen, Adam Murphy, Bao-Li Chang, S Lilly Zheng, M Cristina Leske, Suh-Yuh Wu, Anna M Ray, Anselm J M Hennis, Michael J Thun, John Carpten, Graham Casey, Erin N Carter, Edder R Duarte, Lucy Y Xia, Xin Sheng, Peggy Wan, Loreall C Pooler, Iona Cheng, Kristine R Monroe, Fredrick Schumacher, Loic Le Marchand, Laurence N Kolonel, Stephen J Chanock, David Van Den Berg, Daniel O Stram, Brian E Henderson. Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21. Nature Genetics, 2011; DOI: 10.1038/ng.839

Cite This Page:

University of Southern California. "Apparent genetic link to prostate cancer in African-American men determined." ScienceDaily. ScienceDaily, 24 May 2011. <www.sciencedaily.com/releases/2011/05/110523091533.htm>.
University of Southern California. (2011, May 24). Apparent genetic link to prostate cancer in African-American men determined. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2011/05/110523091533.htm
University of Southern California. "Apparent genetic link to prostate cancer in African-American men determined." ScienceDaily. www.sciencedaily.com/releases/2011/05/110523091533.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com
Robotic Hair Restoration

Robotic Hair Restoration

Ivanhoe (Oct. 1, 2014) A new robotic procedure is changing the way we transplant hair. The ARTAS robot leaves no linear scarring and provides more natural results. Video provided by Ivanhoe
Powered by NewsLook.com
Insertable Cardiac Monitor

Insertable Cardiac Monitor

Ivanhoe (Oct. 1, 2014) A heart monitor the size of a paperclip that can save your life. The “Reveal Linq” allows a doctor to monitor patients with A-Fib on a continuous basis for up to 3 years! Video provided by Ivanhoe
Powered by NewsLook.com
Attacking Superbugs

Attacking Superbugs

Ivanhoe (Oct. 1, 2014) Two weapons hospitals can use to attack superbugs. Scientists in Ireland created a new gel resistant to superbugs, and a robot that can disinfect a room in minutes. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins