Featured Research

from universities, journals, and other organizations

Mechanism behind compound's effects on skin inflammation and cancer progression described

Date:
May 23, 2011
Source:
Brigham and Women's Hospital
Summary:
Researchers have developed a fluorinated analog of glucosamine, which, in a recent study, has been shown to block the synthesis of key carbohydrate structures linked to skin inflammation and cancer progression.

Dr. Chuck Dimitroff, Danielle Hays, Matt Opperman, Dr. Filiberto Cedeno-Laurent and Dr. Steve Barthel.
Credit: Image courtesy of Brigham and Women's Hospital

Charles J. Dimitroff, MS, PhD, and colleagues in the Dimitroff Lab at Brigham and Women's Hospital, have developed a fluorinated analog of glucosamine, which, in a recent study, has been shown to block the synthesis of key carbohydrate structures linked to skin inflammation and cancer progression.

Related Articles


These findings appear in the April 14, 2011, issue of the Journal of Biological Chemistry.

Dr. Dimitroff and colleagues show for the first time that the fluorinated glucosamine therapeutic works not through direct incorporation into growing sugar chains as previously believed but instead blocks the synthesis of a key sugar, UDP-GlcNAc, inside immune cells characteristically involved inflammation and anti-tumor immunity

Accordingly, this report underscores a novel and previously unknown mechanism by which fluorinated glucosamine analogs could shape and reduce inflammation intensity, while boosting anti-tumor immune responses. Such knowledge could prove valuable in the design of new and more potent glucosamine mimetics against disease as well as in treatment strategies to utilize existing glucosamine mimetics more efficiently.

This research was funded by grants from the National Cancer Institute and the National Center for Complementary and Alternative Medicine of the National Institutes of Health.


Story Source:

The above story is based on materials provided by Brigham and Women's Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. R. Barthel, A. Antonopoulos, F. Cedeno-Laurent, L. Schaffer, G. Hernandez, S. A. Patil, S. J. North, A. Dell, K. L. Matta, S. Neelamegham, S. M. Haslam, C. J. Dimitroff. Peracetylated 4-fluoro-glucosamine reduces the content and repertoire of N- and O-glycans without direct incorporation.. Journal of Biological Chemistry, 2011; DOI: 10.1074/jbc.M110.194597

Cite This Page:

Brigham and Women's Hospital. "Mechanism behind compound's effects on skin inflammation and cancer progression described." ScienceDaily. ScienceDaily, 23 May 2011. <www.sciencedaily.com/releases/2011/05/110523121337.htm>.
Brigham and Women's Hospital. (2011, May 23). Mechanism behind compound's effects on skin inflammation and cancer progression described. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2011/05/110523121337.htm
Brigham and Women's Hospital. "Mechanism behind compound's effects on skin inflammation and cancer progression described." ScienceDaily. www.sciencedaily.com/releases/2011/05/110523121337.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
Dads-To-Be Also Experience Hormone Changes During Pregnancy

Dads-To-Be Also Experience Hormone Changes During Pregnancy

Newsy (Dec. 18, 2014) A study from University of Michigan researchers found that expectant fathers see a decrease in testosterone as the baby's birth draws near. Video provided by Newsy
Powered by NewsLook.com
Prenatal Exposure To Pollution Might Increase Autism Risk

Prenatal Exposure To Pollution Might Increase Autism Risk

Newsy (Dec. 18, 2014) Harvard researchers found children whose mothers were exposed to high pollution levels in the third trimester were twice as likely to develop autism. Video provided by Newsy
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins