Featured Research

from universities, journals, and other organizations

Breast cancer linked to obesity gene, new research suggests

Date:
May 23, 2011
Source:
Northwestern Memorial Hospital
Summary:
New research aimed to better identify the genetic factors that lead to breast cancer has uncovered a link between the obesity gene and a higher incidence of breast cancer.

New research aimed to better identify the genetic factors that lead to breast cancer has uncovered a link between the fat mass and obesity associated gene (FTO) and a higher incidence of breast cancer. According to the study conducted at Northwestern Memorial Hospital, people who possess a variant of the FTO gene have up to a 30 percent greater chance of developing breast cancer. Research to identify why the link exists is ongoing, but experts say the finding takes us one step closer to personalized medicine based on genetic risk which would allow for better monitoring and prevention of illness, as well as targeted treatment.

Related Articles


"This is a fascinating early finding, which fits with the known connections between obesity and breast cancer," said Virginia Kaklamani, MD, oncologist at Northwestern Memorial, co-director of the Cancer Genetics Program at the Robert H. Lurie Comprehensive Cancer Center of Northwestern University and lead author of the study.

Each individual carries the FTO gene, but only 18 percent have this variant of the gene. Kaklamani, who specializes in cancer genetics, says testing for the FTO variant is not available currently, but it may be available in the future, similar to how genetic testing for the BRCA gene mutation exists today.

"Ten years ago we didn't know about the BRCA gene mutation which has been linked to breast and ovarian cancer. Today, we offer genetic testing and a specialized clinic for those at risk in order to minimize their risk and detect any indication of cancer early," said Kaklamani, who is also an associate professor of medicine at Northwestern University Feinberg School of Medicine. "This knowledge helps us better identify who is at an increased risk so one day, we can counter that risk through preventative measures and advanced screening."

The research, published in BMC Medical Genetics is part of an ongoing group of studies to further knowledge of genetic risk factors for breast cancer.


Story Source:

The above story is based on materials provided by Northwestern Memorial Hospital. Note: Materials may be edited for content and length.


Journal Reference:

  1. Virginia Kaklamani, Nengjun Yi, Maureen Sadim, Kalliopi Siziopikou, Kui Zhang, Yianfei Xu, Sarah Tofilon, Surbhi Agarwal, Boris Pasche, Christos Mantzoros. The role of the fat mass and obesity associated gene (FTO) in breast cancer risk. BMC Medical Genetics, 2011; 12 (1): 52 DOI: 10.1186/1471-2350-12-52

Cite This Page:

Northwestern Memorial Hospital. "Breast cancer linked to obesity gene, new research suggests." ScienceDaily. ScienceDaily, 23 May 2011. <www.sciencedaily.com/releases/2011/05/110523124402.htm>.
Northwestern Memorial Hospital. (2011, May 23). Breast cancer linked to obesity gene, new research suggests. ScienceDaily. Retrieved February 1, 2015 from www.sciencedaily.com/releases/2011/05/110523124402.htm
Northwestern Memorial Hospital. "Breast cancer linked to obesity gene, new research suggests." ScienceDaily. www.sciencedaily.com/releases/2011/05/110523124402.htm (accessed February 1, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, February 1, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins