Featured Research

from universities, journals, and other organizations

Molecular imaging provides fast and effective diagnosis for patients with fever of unknown origin

Date:
June 6, 2011
Source:
Society of Nuclear Medicine
Summary:
New research highlights molecular imaging's diagnostic potential for patients with fever of unknown origin. Persistent fever can be a warning sign for a range of diseases that could be dangerous if left untreated. A single, full-body molecular imaging scan may give physicians everything they need to narrow down the cause and determine appropriate treatment.

Research presented at SNM's 58th Annual Meeting highlights molecular imaging's diagnostic potential for patients with fever of unknown origin. Persistent fever can be a warning sign for a range of diseases that could be dangerous if left untreated. A single, full-body molecular imaging scan may give physicians everything they need to narrow down the cause and determine appropriate treatment.

Related Articles


"Molecular imaging is used widely throughout the world for oncology, as well as cardiology and neurology, but our research shows that it could be the new frontier for the evaluation of inflammatory disease," says Kozuo Kubota, MD, PhD, chief of nuclear medicine at the National Center for Global Health and Medicine in Tokyo, Japan. "If confirmed by further study, FDG-PET may one day be used as an initial, noninvasive diagnostic tool helping clinicians understand and evaluate fever of unknown origin."

When an individual's temperature reaches 101 degrees Fahrenheit on and off for at least three weeks and health care providers cannot diagnose the cause, the patient is considered to have a fever of unknown origin. Research suggests that fever helps fight off infections, and treating the fever without knowing the cause may reduce the body's ability to deal with possible infection. As a result, patients undergo numerous tests to narrow down the possible causes, such as infections (tuberculosis, mononucleosis, HIV, pneumonia, meningitis), cancer (leukemia, Hodgkin's disease) or collagen vascular disease (Takayasu aortitis).

This study focuses on the use of positron emission tomography (PET) in conjunction with an injected medical isotope called fluorodeoxyglucose (FDG) to determine the cause of the fever of unknown origin. This radiotracer is bound with a glucose analog that is metabolized by the body as energy. Investigators are using FDG-PET to create a visual map of inflammatory disease by targeting the abnormal metabolism of FDG, which points toward the cellular processes causing patients' fever. Physicians can use the information gleaned from FDG-PET scans to guide appropriate treatment, including biopsy or sampling for pathological or bacteriological diagnosis. In the long run, molecular imaging may improve patients' prognosis as well as cut the total cost of care.

In this multi-center retrospective study, 81 patients across six institutions underwent FDG-PET imaging for the evaluation of fever of unknown origin. The use of FDG-PET was then analyzed for its diagnostic performance, ability to provide additional information and clinical impact on therapeutic decisions. Diagnoses were split between four categories: infection; autoimmune hypersensitivity; tumor or granuloma, which is a tumorous mass that develops as a result of inflammation; and all other diagnoses. According to results of this study, FDG-PET may lead to higher diagnostic efficacy for the evaluation of fever of unknown origin, especially in the case of infection and granuloma, and hospitals dedicated to the treatment of these inflammatory diseases show the greatest benefit from FDG-PET imaging.


Story Source:

The above story is based on materials provided by Society of Nuclear Medicine. Note: Materials may be edited for content and length.


Cite This Page:

Society of Nuclear Medicine. "Molecular imaging provides fast and effective diagnosis for patients with fever of unknown origin." ScienceDaily. ScienceDaily, 6 June 2011. <www.sciencedaily.com/releases/2011/06/110606131609.htm>.
Society of Nuclear Medicine. (2011, June 6). Molecular imaging provides fast and effective diagnosis for patients with fever of unknown origin. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/06/110606131609.htm
Society of Nuclear Medicine. "Molecular imaging provides fast and effective diagnosis for patients with fever of unknown origin." ScienceDaily. www.sciencedaily.com/releases/2011/06/110606131609.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins