Featured Research

from universities, journals, and other organizations

Potential treatment for deadly E. coli disease: Australian researchers produce 'designer' probiotic

Date:
June 7, 2011
Source:
University of Adelaide
Summary:
A potential life-saving treatment for severe E. coli food poisoning outbreaks -- developed more than a decade ago -- hasn't gone forward into clinical trials because of lack of commercial interest, Australian researchers say. They have produced a "designer" probiotic bacterium which binds and neutralises the toxin produced by E. coli, which causes life-threatening attack on the kidneys and blood vessels.

The probiotic bacterium (blue) with E. coli Shiga toxin (red) bound all over its surface.
Credit: Image courtesy of University of Adelaide

A potential life-saving treatment for severe E. coli food poisoning outbreaks -- developed more than a decade ago -- hasn't gone forward into clinical trials because of lack of commercial interest, Australian researchers say.

Related Articles


University of Adelaide researchers produced a "designer" probiotic bacterium which binds and neutralises the toxin produced by E. coli, which causes life-threatening attack on the kidneys and blood vessels.

The team of scientists -- Dr Adrienne Paton, Associate Professor Renato Morona and Professor James Paton -- showed that mice infected with a highly virulent strain of E. coli were completely protected by the probiotic bacterium.

The research was published in the journal Nature Medicine in 2000 and generated ongoing interest from the scientific and medical community -- but the commercial sector hasn't taken up its development for progress into clinical trials in humans.

"Severe E. coli food poisoning outbreaks such as that currently occurring in Europe are becoming increasingly common," said Professor Paton, Director, Research Centre for Infectious Diseases at the University of Adelaide.

"They have the potential to cause widespread disease and many patients develop life-threatening complications including kidney failure.

"The probiotic bacterium could be produced cheaply on a large scale. However, in spite of on-going attention from the scientific and medical community, there has been a lack of interest from the commercial sector in taking this product forward into clinical trials.

"If this had been done, and the probiotic had been proven to be safe and efficacious in humans, it could have been deployed during the current European outbreak. This would undoubtedly have saved lives, as well as millions of dollars in current and future health care costs."

The researchers engineered a harmless bacterium to mimic binding receptors for the potentially fatal Shiga toxin on its surface.

Professor Paton said after diagnosis of E. coli infection there was a window of opportunity for therapeutic intervention before kidneys started to fail. Antibiotics are not used because they can increase the amount of toxin released in the gut.


Story Source:

The above story is based on materials provided by University of Adelaide. Note: Materials may be edited for content and length.


Journal Reference:

  1. Adrienne W. Paton, Renato Morona, James C. Paton. A new biological agent for treatment of Shiga toxigenic Escherichia coli infections and dysentery in humans. Nature Medicine, 2000; 6: 265-270 DOI: 10.1038/73111

Cite This Page:

University of Adelaide. "Potential treatment for deadly E. coli disease: Australian researchers produce 'designer' probiotic." ScienceDaily. ScienceDaily, 7 June 2011. <www.sciencedaily.com/releases/2011/06/110607094524.htm>.
University of Adelaide. (2011, June 7). Potential treatment for deadly E. coli disease: Australian researchers produce 'designer' probiotic. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/06/110607094524.htm
University of Adelaide. "Potential treatment for deadly E. coli disease: Australian researchers produce 'designer' probiotic." ScienceDaily. www.sciencedaily.com/releases/2011/06/110607094524.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
The Hottest Food Trends for 2015

The Hottest Food Trends for 2015

Buzz60 (Dec. 17, 2014) Urbanspoon predicts whicg food trends will dominate the culinary scene in 2015. Mara Montalbano (@maramontalbano) has the story. Video provided by Buzz60
Powered by NewsLook.com
Rover Finds More Clues About Possible Life On Mars

Rover Finds More Clues About Possible Life On Mars

Newsy (Dec. 17, 2014) NASA's Curiosity rover detected methane on Mars and organic compounds on the surface, but it doesn't quite prove there was life ... yet. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins