Featured Research

from universities, journals, and other organizations

Mechanism for stress-induced epigenetic inheritance uncovered in new study

Date:
June 23, 2011
Source:
RIKEN
Summary:
Researchers have uncovered a mechanism by which the effects of stress in the fly species Drosophila are inherited epigenetically over many generations through changes to the structure of chromatin, the material that makes up the cell nucleus. The results highlight the role of the transcription factor dATF-2 in chromatin assembly, marking a major advance in our understanding of non-Mendelian inheritance.

Multigenerational inheritance of the disrupted heterochromatin by stress. When the flies were exposed to heat stress only at 1st generation, its effect that can be judged by red eye phenotype was seen in the second generation flies, but not in the successive generations (green). When flies were exposed to heat stress at first and second generations, its effect was observed in the successive three generations (yellow).
Credit: RIKEN

Researchers at RIKEN have uncovered a mechanism by which the effects of stress in the fly species Drosophila are inherited epigenetically over many generations through changes to the structure of chromatin, the material that makes up the cell nucleus. Published in the journal Cell, the results highlight the role of the transcription factor dATF-2 in chromatin assembly, marking a major advance in our understanding of non-Mendelian inheritance.

Related Articles


Recent years have seen growing interest in the phenomenon of epigenetic inheritance: the idea that our genome, through epigenetic tags and other structural modifications, transmits more information than the sequence of letters encoded in its DNA base pairs alone. Stresses of various kinds have been shown to induce such epigenetic change, yet the underlying mechanisms involved remain unknown.

To clarify these mechanisms, the researchers investigated the activity of activation transcription factor-2 (ATF-2), a member of a family of transcription factors which regulate gene expression in response to changes in the cellular environment. Earlier research had suggested that in the absence of stress, ATF-2 plays a role in silencing certain genes through the formation of heterochromatin, a tightly-packed variety of chromatin whose state is epigenetically heritable. When the stress is turned on, ATF-2 changes its function and induces gene expression.

Studying mutations to the ATF-2 gene in Drosophila (dATF-2), the researchers observed a disruption to the heterochromatin structure and reduced methylation of histone proteins, the main component of chromatin. Further analysis revealed that heat shock and osmotic stress during early embryogenesis results in phosphorylation of dATF-2 and triggers its release from the heterochromatin.

Most interestingly, the researchers discovered that the disruption to heterochromatin caused by the release of dATF-2 was transmitted to the next generation of cells, without any change to their DNA sequences. In the case of heat shock, sustained stress over multiple generations resulted in the altered chromatin state being inherited by subsequent generations as well. The findings thus provide the first example of multigenerational transmission of stress-induced epigenetic change, highlighting the role played by ATF-2 and opening promising new avenues for further study.


Story Source:

The above story is based on materials provided by RIKEN. Note: Materials may be edited for content and length.


Journal Reference:

  1. Ki-Hyeon Seong, Dong Li, Hideyuki Shimizu, Ryoichi Nakamura, Shunsuke Ishii. Inheritance of Stress-Induced, ATF-2-Dependent Epigenetic Change. Cell, Volume 145, Issue 7, 1049-1061, 24 June 2011 DOI: 10.1016/j.cell.2011.05.029

Cite This Page:

RIKEN. "Mechanism for stress-induced epigenetic inheritance uncovered in new study." ScienceDaily. ScienceDaily, 23 June 2011. <www.sciencedaily.com/releases/2011/06/110623130328.htm>.
RIKEN. (2011, June 23). Mechanism for stress-induced epigenetic inheritance uncovered in new study. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2011/06/110623130328.htm
RIKEN. "Mechanism for stress-induced epigenetic inheritance uncovered in new study." ScienceDaily. www.sciencedaily.com/releases/2011/06/110623130328.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Kids Die While Under Protective Services

Kids Die While Under Protective Services

AP (Dec. 18, 2014) As part of a six-month investigation of child maltreatment deaths, the AP found that hundreds of deaths from horrific abuse and neglect could have been prevented. AP's Haven Daley reports. (Dec. 18) Video provided by AP
Powered by NewsLook.com
UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins