Featured Research

from universities, journals, and other organizations

Landmark editorial denounces 'poor publication practices' in spine research

Date:
June 28, 2011
Source:
Loyola University Health System
Summary:
A landmark editorial in the nation's leading spine journal is challenging the integrity of published industry-sponsored research involving a bone-growth product. The editorial notes that in 13 trials involving 780 patients, industry-funded researchers did not report a single adverse advent involving Medtronic's Infuse Bone Graft.

Loyola University Hospital spine surgeon Dr. Alexander Ghanayem is co-author of a landmark editorial challenging the integrity of published industry-sponsored research involving a bone-growth product.

The unusually blunt editorial in The Spine Journal notes that in 13 trials involving 780 patients, industry-funded researchers did not report a single adverse advent involving Medtronic's Infuse® Bone Graft. (The product, approved for certain spinal-fusion surgeries, is designed to eliminate the need to harvest bone from the hip.)

The editorial in the nation's leading spine journal notes that the authors of nearly all the trials had financial ties with the manufacturer, with investigators earning as much as $26 million per study.

However, subsequent studies have documented serious adverse events, including inflammatory reactions, cancer, infection and implant dislodgement.

Flawed clinical research of the bone growth product and inadequate disclosure of industry relationships are examples of the problems arising from financial ties between physicians and the medical device and pharmaceutical industries.

"We find ourselves at a precarious intersection of professionalism, morality and public safety," the editorial states. "We work under a burden of suspicion that new technology research and publication is simply a 'broken system' as currently practiced. Our professionalism. . . . is fundamentally challenged by the threat of 'tainted science.'"

The editorial goes on: "It harms patients to have biased and corrupted research published. It harms patients to have unaccountable special interests permeate medical research. It harms patients when poor publication practices become business as usual."

Researchers who have financial ties to industry often say they have too much integrity to allow industry funding to affect their objectivity. The editorial says this "choirboy defense" lacks even minimum credibility.

"Instead the press and public assume that multimillion-dollar compensation packages can and do alter the balance of objectivity."

Ghanayem is a member of the board of directors of the North American Spine Society. He is a professor in the Department of Orthopaedic Surgery and Rehabilitation and division director, Spine Surgery, at Loyola University Chicago Stritch School of Medicine.

Other co-authors of the editorial are Eugene Carragee, MD of Stanford University School of Medicine (first author); Bradley Weiner, MD of Methodist Hospital in Houston; David Rothman, PhD of Columbia University College of Physicians and Surgeons and Christopher Bono, MD of Brigham & Women's Hospital in Boston.


Story Source:

The above story is based on materials provided by Loyola University Health System. Note: Materials may be edited for content and length.


Journal Reference:

  1. Eugene J. Carragee, Alexander J. Ghanayem, Bradley K. Weiner, David J. Rothman, Christopher M. Bono. A challenge to integrity in spine publications: years of living dangerously with the promotion of bone growth factors. The Spine Journal, 2011; 11 (6): 463-468 DOI: 10.1016/j.spinee.2011.06.001

Cite This Page:

Loyola University Health System. "Landmark editorial denounces 'poor publication practices' in spine research." ScienceDaily. ScienceDaily, 28 June 2011. <www.sciencedaily.com/releases/2011/06/110628173757.htm>.
Loyola University Health System. (2011, June 28). Landmark editorial denounces 'poor publication practices' in spine research. ScienceDaily. Retrieved July 25, 2014 from www.sciencedaily.com/releases/2011/06/110628173757.htm
Loyola University Health System. "Landmark editorial denounces 'poor publication practices' in spine research." ScienceDaily. www.sciencedaily.com/releases/2011/06/110628173757.htm (accessed July 25, 2014).

Share This




More Health & Medicine News

Friday, July 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

Beatings and Addiction: Pakistan Drug 'clinic' Tortures Patients

AFP (July 24, 2014) — A so-called drugs rehab 'clinic' is closed down in Pakistan after police find scores of ‘patients’ chained up alleging serial abuse. Duration 03:05 Video provided by AFP
Powered by NewsLook.com
Too Few Teens Receiving HPV Vaccination, CDC Says

Too Few Teens Receiving HPV Vaccination, CDC Says

Newsy (July 24, 2014) — The Centers for Disease Control and Prevention is blaming doctors for the low number of children being vaccinated for HPV. Video provided by Newsy
Powered by NewsLook.com
New Painkiller Designed To Discourage Abuse: Will It Work?

New Painkiller Designed To Discourage Abuse: Will It Work?

Newsy (July 24, 2014) — The FDA approved Targiniq ER on Wednesday, a painkiller designed to keep users from abusing it. Like any new medication, however, it has doubters. Video provided by Newsy
Powered by NewsLook.com
Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Doctor At Forefront Of Fighting Ebola Outbreak Gets Ebola

Newsy (July 24, 2014) — Sheik Umar Khan has treated many of the people infected in the Ebola outbreak, and now he's become one of them. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins